{"id":"W3185917834","doi":"10.3390/cancers13153658","title":"The Small-Molecule Inhibitor MRIA9 Reveals Novel Insights into the Cell Cycle Roles of SIK2 in Ovarian Cancer Cells","year":2021,"lang":"en","type":"article","venue":"Cancers","topic":"Metabolism, Diabetes, and Cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":21,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Deutsche Forschungsgemeinschaft; Deutschen Konsortium für Translationale Krebsforschung; Ontario Genomics Institute; European Federation of Pharmaceutical Industries and Associations; Merck KGaA; Ontario Genomics; Genome Canada; Fundação de Amparo à Pesquisa do Estado de São Paulo; McGill University; Bayer; Genentech; Deutsche Krebshilfe; Pfizer","keywords":"Centrosome; Ovarian cancer; Paclitaxel; Cancer research; Mitosis; Kinase; Cancer cell; Biology; Protein kinase A; AMPK; Cell biology; Cancer; Chemistry; Cell cycle; Genetics","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000198902,0.0001777597,0.0002166956,0.00002438055,0.000133772,0.00003423074,0.0003482603,0.0001365828,0.00003174852],"category_scores_gemma":[0.00004561036,0.0001212867,0.0001151777,0.0002331212,0.0001703156,0.000004752747,0.0001319378,0.0001457752,0.000002870833],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001347121,"about_ca_system_score_gemma":0.0009433535,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007418901,"about_ca_topic_score_gemma":0.007929017,"domain_scores_codex":[0.9987382,0.0001091017,0.0003103866,0.0003708284,0.0001594474,0.0003120906],"domain_scores_gemma":[0.9990424,0.00003647731,0.0001528034,0.0005432075,0.0001512228,0.00007387513],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004660076,0.00002200501,0.0001057041,0.00003654158,0.00004614075,0.000001889375,0.0007912889,0.001311564,0.9877508,0.0001511109,0.001939518,0.007796819],"study_design_scores_gemma":[0.0005886701,0.00002692513,0.0001825574,0.00003516466,0.00002371741,3.079192e-7,0.0006046324,0.00006133643,0.8143746,0.0001070619,0.1838529,0.0001420788],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.737823,0.2599951,0.00007399145,0.0001362817,0.0006492531,0.0001671009,0.00002188201,0.000003723815,0.001129613],"genre_scores_gemma":[0.9294301,0.06804357,0.0001074942,0.001053953,0.0005303212,0.0001281956,0.00001953692,0.00003050187,0.0006563698],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1919516,"threshold_uncertainty_score":0.4945927,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007511820417963855,"score_gpt":0.2270354872608141,"score_spread":0.2195236668428503,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}