{"id":"W3185917834","doi":"10.3390/cancers13153658","title":"The Small-Molecule Inhibitor MRIA9 Reveals Novel Insights into the Cell Cycle Roles of SIK2 in Ovarian Cancer Cells","year":2021,"lang":"en","type":"article","venue":"Cancers","topic":"Metabolism, Diabetes, and Cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":21,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Deutsche Forschungsgemeinschaft; Deutschen Konsortium für Translationale Krebsforschung; Ontario Genomics Institute; European Federation of Pharmaceutical Industries and Associations; Merck KGaA; Ontario Genomics; Genome Canada; Fundação de Amparo à Pesquisa do Estado de São Paulo; McGill University; Bayer; Genentech; Deutsche Krebshilfe; Pfizer","keywords":"Centrosome; Ovarian cancer; Paclitaxel; Cancer research; Mitosis; Kinase; Cancer cell; Biology; Protein kinase A; AMPK; Cell biology; Cancer; Chemistry; Cell cycle; Genetics","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008160324,0.0002705475,0.0002935659,0.0001608891,0.0001284229,0.0002311081,0.0002040324,0.0001817916,0.00134843],"category_scores_gemma":[0.0000552919,0.0001112067,0.0002324795,0.0001094153,0.0001017748,0.0001579052,0.00009620337,0.0005168114,0.0003371982],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002061603,"about_ca_system_score_gemma":0.0002144023,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004601725,"about_ca_topic_score_gemma":0.001195789,"domain_scores_codex":[0.9999616,0.000004320189,0.000003946751,0.000009730332,0.00001083002,0.000009552328],"domain_scores_gemma":[0.9999768,0.000005275391,0.000005202259,0.000003313004,0.000003285696,0.000006118913],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002278842,0.00008571271,0.0001209577,0.00005078174,0.000009312002,0.00005527414,0.000005848815,0.0001779114,0.9942679,0.0002479661,0.0001758805,0.004574336],"study_design_scores_gemma":[0.00006704343,0.0005655473,0.002589678,0.000005467536,0.00002083431,0.000277082,0.00001088372,0.00190689,0.9868122,0.00007630613,0.007662401,0.000005701083],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.972491,0.01111631,0.0060775,0.0007756305,0.0002033022,0.00009086239,0.001491126,0.0003190877,0.007435136],"genre_scores_gemma":[0.9881749,0.004522229,0.0027531,0.0001469157,0.00002204861,0.0000569877,0.0009124461,0.00002140619,0.003389945],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00134843,"threshold_uncertainty_score":0.004510939,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007511820417963855,"score_gpt":0.2270354872608141,"score_spread":0.2195236668428503,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}