{"id":"W3185922159","doi":"10.1038/s41531-021-00203-9","title":"Alpha-synuclein research: defining strategic moves in the battle against Parkinson’s disease","year":2021,"lang":"en","type":"review","venue":"npj Parkinson s Disease","topic":"Parkinson's Disease Mechanisms and Treatments","field":"Medicine","cited_by":178,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ottawa Hospital; University of Ottawa","funders":"National Institute of Neurological Disorders and Stroke; National Health and Medical Research Council; Medical Research Council; National Institutes of Health; H. Lundbeck A/S; Lundbeckfonden; National Institute on Drug Abuse; École Polytechnique Fédérale de Lausanne; Deutsche Forschungsgemeinschaft; Deutsches Zentrum für Neurodegenerative Erkrankungen; Agence Nationale de la Recherche; Parkinson's Foundation; Aarhus Universitet; European Commission; European Federation of Pharmaceutical Industries and Associations; Michael J. Fox Foundation for Parkinson's Research","keywords":"Parkinson's disease; Disease; Battle; Alpha-synuclein; Medicine; Political science; Neuroscience; Psychology; Pathology; History","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":["metaepi_narrow"],"category_scores_codex":[0.001961972,0.001607289,0.003176518,0.001159668,0.0006230197,0.0005896339,0.001209115,0.0005181151,0.0007288269],"category_scores_gemma":[0.00141222,0.001160577,0.002114669,0.002371135,0.0003981409,0.0002679965,0.0004562456,0.002064363,0.001133807],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009533678,"about_ca_system_score_gemma":0.005034375,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00008546472,"about_ca_topic_score_gemma":0.00004081434,"domain_scores_codex":[0.9880743,0.002964287,0.001566999,0.002617697,0.002739808,0.002036911],"domain_scores_gemma":[0.9915522,0.001693537,0.0005432662,0.003054937,0.0003111476,0.002844898],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.001172511,0.009404828,0.005820901,0.03025336,0.001908125,0.06945563,0.0004102531,0.00001602016,0.00000216868,0.008216089,0.01426299,0.8590771],"study_design_scores_gemma":[0.001928305,0.0001422804,0.006068848,0.01990111,0.003405358,0.00004224114,0.0004549306,0.00009811464,7.933359e-7,0.0006532104,0.9663149,0.000989882],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.005501181,0.9843206,0.000003633536,0.0004300393,0.000665414,0.00302987,0.001826654,0.0001852658,0.004037291],"genre_scores_gemma":[0.05133,0.9395864,0.0001610836,0.000694081,0.0006094822,0.002837949,0.00392969,0.0003451167,0.0005062039],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9520519,"threshold_uncertainty_score":0.9996675,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1900603234432968,"score_gpt":0.4009510730955972,"score_spread":0.2108907496523004,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}