{"id":"W3185960843","doi":"10.1039/d1sc03356e","title":"Unprecedented polycyclic polyprenylated acylphloroglucinols with anti-Alzheimer's activity from St. John's wort","year":2021,"lang":"en","type":"article","venue":"Chemical Science","topic":"Natural Compound Pharmacology Studies","field":"Agricultural and Biological Sciences","cited_by":37,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Science Fund for Distinguished Young Scholars; Tongji University; Huazhong University of Science and Technology; Ministry of Education of the People's Republic of China; National Outstanding Youth Science Fund Project of National Natural Science Foundation of China; National Natural Science Foundation of China; Innovative Research Group Project of the National Natural Science Foundation of China","keywords":"Natural product; Chemistry; Stereochemistry","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000162776,0.0002446812,0.0003066442,0.00001519415,0.0004931645,0.0001420997,0.0007384999,0.0001154127,0.0004719488],"category_scores_gemma":[0.0001215217,0.00009558695,0.00007888849,0.001837259,0.0009285859,0.0003895373,0.0004472559,0.0003777367,0.00003761482],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007465891,"about_ca_system_score_gemma":0.00006234233,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004194263,"about_ca_topic_score_gemma":0.000202746,"domain_scores_codex":[0.9976999,0.00006019774,0.0001800685,0.0008597026,0.0005524301,0.0006476879],"domain_scores_gemma":[0.9989573,0.0003637407,0.0001053677,0.0001364738,0.0001518181,0.0002853503],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004996981,0.0001090623,0.0115395,6.897343e-7,0.00005097715,0.00002659552,0.0000296696,6.451936e-7,0.9768876,0.000007462488,0.0002894953,0.01100836],"study_design_scores_gemma":[0.0001937448,0.00004102424,0.1993493,0.00001623247,0.00004336223,0.00001467726,0.00005047841,0.00004663688,0.7980127,0.0001022889,0.001888839,0.0002407722],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9944951,0.0007775953,0.00000124973,0.003376139,0.0002189226,0.0001473439,0.00004391297,0.0001569686,0.0007827922],"genre_scores_gemma":[0.9988844,0.00004518659,0.0001920258,0.0005643078,0.0001928373,0.00001162032,0.00004425712,0.000001538534,0.00006386748],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1878098,"threshold_uncertainty_score":0.5167508,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02431012481516258,"score_gpt":0.2598348871546625,"score_spread":0.2355247623394999,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}