{"id":"W3185970817","doi":"10.1016/j.nano.2021.102443","title":"Synthetic multiepitope neoantigen DNA vaccine for personalized cancer immunotherapy","year":2021,"lang":"en","type":"article","venue":"Nanomedicine Nanotechnology Biology and Medicine","topic":"Immunotherapy and Immune Responses","field":"Immunology and Microbiology","cited_by":40,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of British Columbia","funders":"Fundamental Research Funds for the Central Universities; National Natural Science Foundation of China","keywords":"DNA vaccination; Immunotherapy; Virology; Biology; Cancer immunotherapy; Vaccination; Adjuvant; Immune system; Immunology; Cancer research; Immunization","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001396461,0.0002113893,0.0001493651,0.0001392452,0.00009301466,0.0002577972,0.0001807635,0.0003520754,0.001732576],"category_scores_gemma":[0.0001669652,0.0001097026,0.000132407,0.0001023946,0.0001368986,0.0002687666,0.0003005734,0.0005137642,0.0005913752],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002408722,"about_ca_system_score_gemma":0.0002582087,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00009721918,"about_ca_topic_score_gemma":0.0001578999,"domain_scores_codex":[0.9999245,0.00001516555,0.000004012327,0.00001604079,0.00002402596,0.00001614332],"domain_scores_gemma":[0.9999461,0.00001078241,0.00001453159,0.000005477744,0.000009874073,0.00001320265],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007603551,0.00007151136,0.0001823138,0.00007584844,0.000007117094,0.00005315494,0.0000139734,0.0008503498,0.9880021,0.001085194,0.0002634099,0.009318993],"study_design_scores_gemma":[0.00004601526,0.0009802295,0.0007051188,0.00001385404,0.00002602723,0.0003987912,0.00002771044,0.005711683,0.9770462,0.0007840452,0.01425187,0.000008463401],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9219355,0.006445108,0.06026434,0.001032262,0.0005695954,0.0001676157,0.0004202545,0.0003137559,0.008851512],"genre_scores_gemma":[0.9773119,0.001598816,0.01414372,0.0003276184,0.0000450883,0.00007644381,0.0002601332,0.0000218106,0.006214476],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001732576,"threshold_uncertainty_score":0.005796075,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01326849025072416,"score_gpt":0.2989271089233566,"score_spread":0.2856586186726324,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}