{"id":"W3185970817","doi":"10.1016/j.nano.2021.102443","title":"Synthetic multiepitope neoantigen DNA vaccine for personalized cancer immunotherapy","year":2021,"lang":"en","type":"article","venue":"Nanomedicine Nanotechnology Biology and Medicine","topic":"Immunotherapy and Immune Responses","field":"Immunology and Microbiology","cited_by":40,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of British Columbia","funders":"Fundamental Research Funds for the Central Universities; National Natural Science Foundation of China","keywords":"DNA vaccination; Immunotherapy; Virology; Biology; Cancer immunotherapy; Vaccination; Adjuvant; Immune system; Immunology; Cancer research; Immunization","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","research_integrity","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0008126172,0.0005452424,0.001404386,0.0004703534,0.0004877887,0.000006140899,0.0004115395,0.001373243,0.002089683],"category_scores_gemma":[0.0009761722,0.0004013467,0.000170381,0.0004864822,0.00227547,0.00007066833,0.0001219183,0.0006665862,0.00003635761],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006467226,"about_ca_system_score_gemma":0.0002597524,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001449412,"about_ca_topic_score_gemma":0.00002878655,"domain_scores_codex":[0.9968851,0.0003777111,0.0008213084,0.0009363196,0.00005671336,0.0009228286],"domain_scores_gemma":[0.9975851,0.001002619,0.0003105162,0.0007111655,0.0003353589,0.0000552977],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.001784026,0.0001314785,0.001883565,0.00005272586,0.0007495659,0.00001776251,0.0005499346,1.594256e-7,0.8575798,0.007315798,0.002923292,0.1270119],"study_design_scores_gemma":[0.01494915,0.001560851,0.001644965,0.0002606485,0.0002039944,0.0006598926,0.0008766129,0.000004389955,0.2951773,0.001528646,0.6827503,0.0003832482],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.5733725,0.381357,0.002625287,0.03802017,0.003117187,0.0008334157,0.00007034208,0.0004842562,0.0001199355],"genre_scores_gemma":[0.9025733,0.07316189,0.0004192785,0.006074551,0.0003820729,0.0005728808,0.0004679526,0.0001339579,0.01621408],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.6798271,"threshold_uncertainty_score":0.9999232,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01326849025072416,"score_gpt":0.2989271089233566,"score_spread":0.2856586186726324,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}