{"id":"W3185980680","doi":"10.1002/cbic.202100334","title":"Building siRNAs with Cubes: Synthesis and Evaluation of Cubane‐Modified siRNAs","year":2021,"lang":"en","type":"article","venue":"ChemBioChem","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ontario Tech University","funders":"","keywords":"Cubane; Small interfering RNA; Gene silencing; Trans-acting siRNA; RNA interference; Chemistry; RNA; Stereochemistry; Combinatorial chemistry; Biochemistry; Gene; Molecule; Organic chemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002739663,0.0003567,0.0002991691,0.0001776991,0.0001721843,0.0002827532,0.000231924,0.0003120274,0.0007868523],"category_scores_gemma":[0.0002693828,0.0001568387,0.0001822632,0.0001545598,0.0001944453,0.0002010582,0.0002423916,0.000326588,0.000334914],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003553312,"about_ca_system_score_gemma":0.0002583808,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008669998,"about_ca_topic_score_gemma":0.001135239,"domain_scores_codex":[0.9998246,0.00004159176,0.00001880364,0.00003576408,0.00004977968,0.00002939638],"domain_scores_gemma":[0.9998472,0.00002634247,0.00003449791,0.00001657956,0.00004096232,0.00003447512],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008308444,0.00003093535,0.00007054918,0.00007229704,0.00000777471,0.00007399649,0.00002170505,0.0005686489,0.9971324,0.0001371545,0.00006134734,0.001740175],"study_design_scores_gemma":[0.00001101615,0.0002522513,0.0001679814,0.000003038303,0.000005066827,0.00006253687,0.000008344008,0.001187433,0.9968418,0.00001634552,0.001437513,0.000006610759],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9824076,0.001251668,0.01196944,0.000132139,0.00004298087,0.0002279683,0.0004340844,0.0002413135,0.003292715],"genre_scores_gemma":[0.9643895,0.0009017965,0.03058683,0.00009711951,0.000008300622,0.0002156253,0.000725051,0.00008360624,0.002992187],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008669998,"threshold_uncertainty_score":0.00263226,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02428320856971742,"score_gpt":0.2755782376834982,"score_spread":0.2512950291137808,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}