{"id":"W3185980680","doi":"10.1002/cbic.202100334","title":"Building siRNAs with Cubes: Synthesis and Evaluation of Cubane‐Modified siRNAs","year":2021,"lang":"en","type":"article","venue":"ChemBioChem","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ontario Tech University","funders":"","keywords":"Cubane; Small interfering RNA; Gene silencing; Trans-acting siRNA; RNA interference; Chemistry; RNA; Stereochemistry; Combinatorial chemistry; Biochemistry; Gene; Molecule; Organic chemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002532142,0.0001382084,0.000165602,0.00002783977,0.00003979788,0.00002079145,0.0001049046,0.000122002,0.00003558953],"category_scores_gemma":[0.0002062148,0.0001265997,0.00005523562,0.00009020329,0.00008193056,0.000005155067,0.00008276413,0.00005410702,0.000002223646],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001423364,"about_ca_system_score_gemma":0.0001553419,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000103519,"about_ca_topic_score_gemma":0.00001259527,"domain_scores_codex":[0.9990477,0.00004779713,0.0001687349,0.0003535378,0.000224842,0.0001573999],"domain_scores_gemma":[0.9990831,0.00002120994,0.0000842401,0.0003286352,0.000424799,0.00005801221],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005661299,0.00004909984,0.0004741998,0.0000400524,0.00009514852,0.000002878277,0.00004528258,0.00007011113,0.9918889,0.00006150753,0.000249178,0.006967043],"study_design_scores_gemma":[0.0004362379,0.00009467608,0.0007490549,0.00008352396,0.0001143639,0.00003277192,0.0002081581,0.0003358258,0.9972239,0.00009283931,0.0004648345,0.0001638823],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9938296,0.002564108,0.0003920475,0.00007513553,0.00004255825,0.00009137022,0.000008649037,0.000006613072,0.002989937],"genre_scores_gemma":[0.9983804,0.0002495282,0.0008987405,0.00006979774,0.00008856145,0.00002587283,0.00003607563,0.00001635944,0.0002346511],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006803161,"threshold_uncertainty_score":0.5162585,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02428320856971742,"score_gpt":0.2755782376834982,"score_spread":0.2512950291137808,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}