{"id":"W3185992264","doi":"10.1161/circgen.120.003271","title":"Sex-Specific Associations of Genetically Predicted Circulating Lp(a) (Lipoprotein(a)) and Hepatic <i>LPA</i> Gene Expression Levels With Cardiovascular Outcomes: Mendelian Randomization and Observational Analyses","year":2021,"lang":"en","type":"article","venue":"Circulation Genomic and Precision Medicine","topic":"Lipoproteins and Cardiovascular Health","field":"Medicine","cited_by":34,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval; Institut universitaire de cardiologie et de pneumologie de Québec","funders":"Common Fund; National Human Genome Research Institute; National Institute on Drug Abuse; Cancer Research UK; NIH Office of the Director; National Heart, Lung, and Blood Institute; National Institute of Mental Health; Medical Research Council; National Institute of Neurological Disorders and Stroke; National Institute for Health and Care Research; Canadian Institutes of Health Research; National Institutes of Health; National Cancer Institute; British Heart Foundation","keywords":"Mendelian randomization; Observational study; Biology; Gene; Genetics; Lipoprotein(a); Lipoprotein; Mendelian inheritance; Internal medicine; Endocrinology; Medicine; Genetic variants; Cholesterol; Genotype","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001590417,0.0002857916,0.001235758,0.000208664,0.0002762309,0.00003341964,0.00005158834,0.0001920182,0.00006835492],"category_scores_gemma":[0.0005656179,0.0002147691,0.0001769087,0.0004230059,0.0001782899,0.0001344108,0.00007039869,0.0001889692,5.5953e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009064154,"about_ca_system_score_gemma":0.0001966447,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001013234,"about_ca_topic_score_gemma":0.000008024159,"domain_scores_codex":[0.996711,0.0003826377,0.0009093471,0.0006593669,0.001100227,0.0002374507],"domain_scores_gemma":[0.9978595,0.0003433714,0.000303302,0.0006093396,0.0006090346,0.0002754595],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0003832825,0.0001388116,0.3675785,0.0007060138,0.002426707,0.00005923022,0.002193496,0.005739282,0.4885799,0.0002237855,0.00005971722,0.1319112],"study_design_scores_gemma":[0.0108986,0.0001600103,0.9734036,0.0004836173,0.0009688378,0.0002480421,0.0003304386,0.007048372,0.005482366,0.00038792,0.0003500448,0.0002381663],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8571202,0.01692048,0.1242175,0.0004455044,0.00007098214,0.001017928,0.00004237548,0.0000362849,0.0001287808],"genre_scores_gemma":[0.9826301,0.002322753,0.01406774,0.000238461,0.0002299453,0.00004557852,0.0003906745,0.00003889262,0.00003585863],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.6058251,"threshold_uncertainty_score":0.8758031,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09128549761471672,"score_gpt":0.3128661464496531,"score_spread":0.2215806488349364,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}