{"id":"W3185992264","doi":"10.1161/circgen.120.003271","title":"Sex-Specific Associations of Genetically Predicted Circulating Lp(a) (Lipoprotein(a)) and Hepatic <i>LPA</i> Gene Expression Levels With Cardiovascular Outcomes: Mendelian Randomization and Observational Analyses","year":2021,"lang":"en","type":"article","venue":"Circulation Genomic and Precision Medicine","topic":"Lipoproteins and Cardiovascular Health","field":"Medicine","cited_by":34,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval; Institut universitaire de cardiologie et de pneumologie de Québec","funders":"Common Fund; National Human Genome Research Institute; National Institute on Drug Abuse; Cancer Research UK; NIH Office of the Director; National Heart, Lung, and Blood Institute; National Institute of Mental Health; Medical Research Council; National Institute of Neurological Disorders and Stroke; National Institute for Health and Care Research; Canadian Institutes of Health Research; National Institutes of Health; National Cancer Institute; British Heart Foundation","keywords":"Mendelian randomization; Observational study; Biology; Gene; Genetics; Lipoprotein(a); Lipoprotein; Mendelian inheritance; Internal medicine; Endocrinology; Medicine; Genetic variants; Cholesterol; Genotype","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.01074483,0.0006452362,0.0008276138,0.0006285521,0.0005131429,0.0007194946,0.001129317,0.0008720825,0.001336727],"category_scores_gemma":[0.01253429,0.0005510264,0.002113475,0.0009632467,0.0007186441,0.0002901207,0.0005152774,0.0007311048,0.000170093],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005374982,"about_ca_system_score_gemma":0.0005768448,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004587956,"about_ca_topic_score_gemma":0.002761543,"domain_scores_codex":[0.9917936,0.005334781,0.0004944592,0.001537466,0.0005237034,0.000316028],"domain_scores_gemma":[0.9897154,0.003724574,0.00294545,0.002865026,0.0003908522,0.0003587088],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.01758382,0.0002443301,0.965502,0.00009080487,0.00702774,0.0002742998,0.0002062153,0.0009879457,0.001663366,0.000507688,0.0006179344,0.005293828],"study_design_scores_gemma":[0.002402129,0.002600304,0.9743881,0.00004021957,0.004683371,0.001025671,0.0001487647,0.01085282,0.001045263,0.001354257,0.001397769,0.0000612429],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9956303,0.0004197031,0.002665537,0.00007071125,0.00001841808,0.00008232531,0.0008774535,0.00002683031,0.0002088211],"genre_scores_gemma":[0.9966477,0.0001245859,0.002013137,0.00004857966,0.00001359262,0.0001467257,0.0007565561,0.0000124614,0.0002367648],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01074483,"threshold_uncertainty_score":0.0568248,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09128549761471672,"score_gpt":0.3128661464496531,"score_spread":0.2215806488349364,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}