{"id":"W3186005391","doi":"10.1084/jem.20210108","title":"Anti-tumor immunity in mismatch repair-deficient colorectal cancers requires type I IFN–driven CCL5 and CXCL10","year":2021,"lang":"en","type":"article","venue":"The Journal of Experimental Medicine","topic":"Immune Cell Function and Interaction","field":"Immunology and Microbiology","cited_by":130,"is_retracted":false,"has_abstract":true,"ca_institutions":"Royal Alexandra Hospital; University of Alberta","funders":"Natural Sciences and Engineering Research Council of Canada; University Hospital Foundation; Canadian Institutes of Health Research; Cancer Research Society","keywords":"CCL5; CXCL10; Cancer research; CD8; Priming (agriculture); Cytotoxic T cell; Immunotherapy; Colorectal cancer; Immunology; Biology; Immunity; Chemokine; T cell; Immune system; Cancer; IL-2 receptor; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0004408984,0.000111301,0.0002928164,0.00008850609,0.000127299,0.000004817614,0.0001058806,0.00005706893,0.001257414],"category_scores_gemma":[0.00015653,0.00007113169,0.00005043123,0.000155603,0.0002735134,0.00009391673,0.00006344188,0.0004120456,0.00001870574],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001684387,"about_ca_system_score_gemma":0.00009343808,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004667951,"about_ca_topic_score_gemma":0.00003082204,"domain_scores_codex":[0.9989461,0.0003208398,0.0004214308,0.0000904103,0.00006365767,0.0001576175],"domain_scores_gemma":[0.9993608,0.0001300939,0.0002308592,0.0001348478,0.0001208366,0.00002254241],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0008720741,0.0001276447,0.0008929814,0.000005792009,0.00008711906,0.00003784035,0.00420242,0.00001136064,0.9841215,0.00003170962,0.009496938,0.0001126324],"study_design_scores_gemma":[0.003013977,0.00203167,0.01036919,0.0002919487,0.00006659503,0.003235719,0.04181535,0.0000308667,0.9201732,0.00000844223,0.01884764,0.0001153632],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9608843,0.03332475,0.000004157172,0.0007573337,0.003836946,0.00007592938,6.111431e-7,0.00001039677,0.00110558],"genre_scores_gemma":[0.9977851,0.0008233337,0.00001635024,0.0004228013,0.00006799745,0.000001407918,0.000008013668,0.00000843907,0.0008665751],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.06394825,"threshold_uncertainty_score":0.9996555,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01808468759920681,"score_gpt":0.2862899938721951,"score_spread":0.2682053062729883,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}