{"id":"W3186005391","doi":"10.1084/jem.20210108","title":"Anti-tumor immunity in mismatch repair-deficient colorectal cancers requires type I IFN–driven CCL5 and CXCL10","year":2021,"lang":"en","type":"article","venue":"The Journal of Experimental Medicine","topic":"Immune Cell Function and Interaction","field":"Immunology and Microbiology","cited_by":130,"is_retracted":false,"has_abstract":true,"ca_institutions":"Royal Alexandra Hospital; University of Alberta","funders":"Natural Sciences and Engineering Research Council of Canada; University Hospital Foundation; Canadian Institutes of Health Research; Cancer Research Society","keywords":"CCL5; CXCL10; Cancer research; CD8; Priming (agriculture); Cytotoxic T cell; Immunotherapy; Colorectal cancer; Immunology; Biology; Immunity; Chemokine; T cell; Immune system; Cancer; IL-2 receptor; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001984257,0.0003068811,0.0001933219,0.0001769272,0.00009510406,0.000237752,0.0001140174,0.0002073496,0.0008950708],"category_scores_gemma":[0.0001031534,0.0001115549,0.0001548323,0.00008874839,0.0001987997,0.0002100653,0.0001728286,0.0006309348,0.0002853332],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000236513,"about_ca_system_score_gemma":0.0001757774,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002282719,"about_ca_topic_score_gemma":0.0004822162,"domain_scores_codex":[0.9998135,0.00005163726,0.00001951695,0.00002647807,0.00002573288,0.00006317264],"domain_scores_gemma":[0.9998908,0.00001556184,0.00002612386,0.00001417354,0.000007476614,0.00004588607],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002091181,0.00004750782,0.0002671493,0.00003091625,0.000001441243,0.00003233655,0.00001189212,0.00005199017,0.9981967,0.00008662529,0.00003812943,0.001026419],"study_design_scores_gemma":[0.0000618288,0.000845083,0.009376787,0.00001219113,0.00001150336,0.0003995283,0.00006322577,0.001652674,0.9853286,0.00007482235,0.002168593,0.000005140609],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9975923,0.0005508667,0.0009870126,0.00007309643,0.00001553729,0.00001561174,0.0001224268,0.00005246453,0.0005907067],"genre_scores_gemma":[0.9975954,0.0002226633,0.001112022,0.00004143421,0.000007788237,0.00002686712,0.0001810129,0.000008446185,0.0008043409],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008950708,"threshold_uncertainty_score":0.002994359,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01808468759920681,"score_gpt":0.2862899938721951,"score_spread":0.2682053062729883,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}