{"id":"W3186025133","doi":"10.1080/03630269.2021.1956947","title":"Hb Calgary (<i>HBB</i>: c.194G&gt;T): A Highly Unstable Hemoglobin Variant with a β-Thalassemia Major Phenotype","year":2021,"lang":"en","type":"article","venue":"Hemoglobin","topic":"Hemoglobinopathies and Related Disorders","field":"Medicine","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"Universitetet i Oslo","keywords":"Missense mutation; Phenotype; Thalassemia; Hemoglobin; Hemolytic anemia; Genetics; Hemoglobinopathy; Pathogenesis; Hemoglobin s; Compound heterozygosity; Anemia; Globin; Biology; Medicine; Gene; Immunology; Internal medicine; Sickle cell anemia","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001458192,0.001882586,0.0005042597,0.001066043,0.0008002738,0.0006719361,0.000673669,0.001738911,0.001825091],"category_scores_gemma":[0.001225562,0.0003308929,0.0003098111,0.0006974459,0.00146015,0.000324001,0.001277483,0.001380135,0.0004794514],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005056703,"about_ca_system_score_gemma":0.0003105465,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003382733,"about_ca_topic_score_gemma":0.002059726,"domain_scores_codex":[0.9997246,0.00002172008,0.00002158071,0.0001056331,0.00004915977,0.00007734692],"domain_scores_gemma":[0.9994676,0.0001392009,0.0001339955,0.00002719962,0.00002515481,0.0002069367],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"case_report","study_design_gemma":"case_report","study_design_scores_codex":[0.00007262153,0.0000705053,0.03396536,0.00005299431,0.00002279027,0.950595,0.0008258242,0.0001554749,0.006456774,0.0007427294,0.0008117,0.006228276],"study_design_scores_gemma":[0.00002079407,0.0001500404,0.04102632,0.00001972818,0.00002731083,0.9531892,0.0002830712,0.0001982022,0.002282826,0.0003522777,0.002420725,0.00002960791],"study_design_candidate":"case_report","study_design_consensus":"case_report","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9830215,0.002463736,0.004299568,0.002438514,0.0003639644,0.0001657979,0.0003631685,0.00009819475,0.006785658],"genre_scores_gemma":[0.995918,0.0005373416,0.001194077,0.0005889916,0.0001591109,0.00001773876,0.0001338419,0.00002302194,0.001428014],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003382733,"threshold_uncertainty_score":0.006726086,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006098099771596323,"score_gpt":0.2145277268923872,"score_spread":0.2084296271207909,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}