{"id":"W3186039091","doi":"10.1016/j.clml.2021.07.017","title":"Comparison of the Effectiveness and Safety of the Oral Selective Inhibitor of Nuclear Export, Selinexor, in Diffuse Large B Cell Lymphoma Subtypes","year":2021,"lang":"en","type":"article","venue":"Clinical Lymphoma Myeloma & Leukemia","topic":"Nuclear Structure and Function","field":"Biochemistry, Genetics and Molecular Biology","cited_by":9,"is_retracted":false,"has_abstract":false,"ca_institutions":"Princess Margaret Cancer Centre","funders":"Karyopharm Therapeutics","keywords":"Medicine; Lymphoma; Diffuse large B-cell lymphoma; Nuclear export signal; Cancer research; Pharmacology; Internal medicine; Cell nucleus; Psychiatry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007108397,0.0002821454,0.00119285,0.0002580381,0.0001532083,0.0005427273,0.0002814901,0.0003781522,0.001933812],"category_scores_gemma":[0.001280373,0.0001252184,0.0005063738,0.0002150691,0.000410167,0.0005956761,0.000184196,0.0008642857,0.0002492351],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005113115,"about_ca_system_score_gemma":0.0003273358,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005499825,"about_ca_topic_score_gemma":0.001277121,"domain_scores_codex":[0.9997194,0.0001095439,0.000024654,0.00004749538,0.00003941856,0.00005936752],"domain_scores_gemma":[0.9994222,0.000248576,0.00008450818,0.0000598529,0.00004362851,0.0001412929],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.4955678,0.005418351,0.02286896,0.0006430678,0.001183513,0.0002895941,0.000273962,0.002433688,0.04950416,0.0007717896,0.001211935,0.4198332],"study_design_scores_gemma":[0.06263189,0.6416026,0.2049035,0.000233231,0.003402763,0.001764474,0.0009884824,0.005800515,0.05947342,0.001175693,0.01791132,0.0001120507],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9917614,0.005729221,0.0002091377,0.0001448026,0.00003962245,0.00003682871,0.0002023376,0.00002133731,0.001855366],"genre_scores_gemma":[0.9968629,0.001530173,0.0001278872,0.00007269378,0.00004835408,0.00003359937,0.0002934523,0.000009381467,0.001021528],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001933812,"threshold_uncertainty_score":0.00646925,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01053148998222008,"score_gpt":0.2794411550550897,"score_spread":0.2689096650728696,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}