{"id":"W3186079455","doi":"10.1038/s41590-021-00984-4","title":"Human autoinflammatory disease reveals ELF4 as a transcriptional regulator of inflammation","year":2021,"lang":"en","type":"article","venue":"Nature Immunology","topic":"Inflammasome and immune disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":105,"is_retracted":false,"has_abstract":false,"ca_institutions":"SickKids Foundation; University of Toronto","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; National Institute of Allergy and Infectious Diseases; U.S. Department of Health and Human Services; National Institutes of Health; Canada Research Chairs; Yale Cancer Center; Canadian Institutes of Health Research; National Science Foundation; Charles H. Hood Foundation; Yale University; G. Harold and Leila Y. Mathers Foundation; Leona M. and Harry B. Helmsley Charitable Trust; Immune Deficiency Foundation","keywords":"Inflammation; Immunology; Tumor necrosis factor alpha; Innate immune system; Transcription factor; Inflammatory bowel disease; Biology; Immune system; Medicine; Disease; Gene; Genetics; Pathology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001827788,0.0002863322,0.0002831052,0.0003174967,0.0001886654,0.0003909332,0.0002629686,0.000379699,0.001918363],"category_scores_gemma":[0.0001434657,0.0001325162,0.0002604205,0.000203858,0.0004245832,0.0001847053,0.0002299906,0.0004761068,0.0004453729],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003503123,"about_ca_system_score_gemma":0.000168665,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004011474,"about_ca_topic_score_gemma":0.0003408847,"domain_scores_codex":[0.9999121,0.00001527091,0.00000540917,0.00002146619,0.0000195586,0.00002619614],"domain_scores_gemma":[0.9999417,0.00001196394,0.00001470331,0.00001001191,0.000007390237,0.00001421742],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00162475,0.00006612716,0.006416126,0.00008419389,0.00004022344,0.001403015,0.00004736814,0.0007578848,0.97328,0.002131022,0.0006523815,0.01349682],"study_design_scores_gemma":[0.0001630096,0.0004720481,0.0476112,0.000045099,0.0001036211,0.006062319,0.000205515,0.004209683,0.9109017,0.004105065,0.02609222,0.00002857016],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9760637,0.007914742,0.009808534,0.001139423,0.0001389761,0.00002287127,0.0008175925,0.000161492,0.003932728],"genre_scores_gemma":[0.9923308,0.001126,0.002618393,0.0002765925,0.0000355907,0.00001565412,0.0006511637,0.00002008906,0.002925694],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001918363,"threshold_uncertainty_score":0.006417632,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.003181847170531817,"score_gpt":0.2383117805791431,"score_spread":0.2351299334086113,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}