{"id":"W3186116012","doi":"10.3390/cancers13153675","title":"Optimization of New Catalytic Topoisomerase II Inhibitors as an Anti-Cancer Therapy","year":2021,"lang":"en","type":"article","venue":"Cancers","topic":"Cancer therapeutics and mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":18,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Terry Fox Research Institute","keywords":"Topoisomerase; Cardiotoxicity; Cancer cell; Chemistry; Cancer; Mechanism of action; Drug; DNA damage; Pharmacology; Cell growth; Small molecule; Cancer research; DNA; Biochemistry; Biology; Toxicity; Medicine; In vitro; Internal medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0000427494,0.0001172079,0.0001363932,0.00002525682,0.00006068794,0.00001277654,0.0001039772,0.00009271656,0.000233119],"category_scores_gemma":[0.00000731354,0.0001202864,0.00007247419,0.0001268065,0.00003612184,0.000006663805,0.00004066732,0.00004547448,0.000001005256],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009428301,"about_ca_system_score_gemma":0.001296449,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005589415,"about_ca_topic_score_gemma":0.0001361725,"domain_scores_codex":[0.9992885,0.00001748311,0.0001487718,0.0002819403,0.0001056529,0.0001576459],"domain_scores_gemma":[0.9994021,0.000001830769,0.00008026465,0.0002970705,0.0001128487,0.000105909],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000820618,0.00002732299,0.00007401964,0.000010437,0.00008174474,0.000001855518,0.0002161701,0.03042086,0.9488997,0.0001316426,0.0009509611,0.01910315],"study_design_scores_gemma":[0.0007754523,0.0002775042,0.00001863565,0.00001365067,0.00001452808,0.000003400198,0.000146349,0.0003958109,0.9329876,0.00007058485,0.06514893,0.0001475841],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9908696,0.005816421,0.001907689,0.0002138412,0.0005448996,0.0001250734,0.00003665923,0.00001035748,0.000475474],"genre_scores_gemma":[0.984269,0.009223002,0.0006574208,0.001164218,0.0004554838,0.00001869404,0.0001912683,0.00003190559,0.003989023],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.06419797,"threshold_uncertainty_score":0.4905136,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01742337458443352,"score_gpt":0.2847295755574595,"score_spread":0.2673062009730259,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}