{"id":"W3186116012","doi":"10.3390/cancers13153675","title":"Optimization of New Catalytic Topoisomerase II Inhibitors as an Anti-Cancer Therapy","year":2021,"lang":"en","type":"article","venue":"Cancers","topic":"Cancer therapeutics and mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":18,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Terry Fox Research Institute","keywords":"Topoisomerase; Cardiotoxicity; Cancer cell; Chemistry; Cancer; Mechanism of action; Drug; DNA damage; Pharmacology; Cell growth; Small molecule; Cancer research; DNA; Biochemistry; Biology; Toxicity; Medicine; In vitro; Internal medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002993303,0.0005920121,0.0006665527,0.0004049431,0.0001529052,0.000668644,0.0004093278,0.0002809474,0.001812691],"category_scores_gemma":[0.0001741178,0.0002279205,0.0003404615,0.0004078327,0.0001760909,0.0004187226,0.0002207513,0.0005628201,0.0005204424],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004334303,"about_ca_system_score_gemma":0.0005080074,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006657905,"about_ca_topic_score_gemma":0.001666951,"domain_scores_codex":[0.9998529,0.00002402655,0.00001229197,0.0000360073,0.00005082998,0.00002396851],"domain_scores_gemma":[0.9999373,0.000008874303,0.00001807349,0.000003875236,0.00001539734,0.0000164391],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000698915,0.0005312258,0.0008127564,0.0006853171,0.00008611239,0.0002954001,0.00003916972,0.01420791,0.9286425,0.002059214,0.0007697555,0.05117179],"study_design_scores_gemma":[0.0005536621,0.006146559,0.003476863,0.00007575437,0.0002358744,0.000637294,0.0000566551,0.02019875,0.9159185,0.0007865156,0.0518582,0.00005545194],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.883583,0.05118342,0.04926629,0.0006773576,0.0001974342,0.0005421083,0.001473106,0.0004410808,0.01263627],"genre_scores_gemma":[0.9213062,0.03557666,0.03605424,0.0002579838,0.00005085126,0.000306627,0.001261788,0.00006869758,0.005116998],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001812691,"threshold_uncertainty_score":0.006064057,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01742337458443352,"score_gpt":0.2847295755574595,"score_spread":0.2673062009730259,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}