{"id":"W3186137940","doi":"10.1016/j.ymeth.2021.07.008","title":"Microfabricated disk technology: Rapid scale up in midbrain organoid generation","year":2021,"lang":"en","type":"article","venue":"Methods","topic":"Pluripotent Stem Cells Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":22,"is_retracted":false,"has_abstract":true,"ca_institutions":"Montreal Neurological Institute and Hospital; McGill University","funders":"Parkinson Canada; Canadian Institutes of Health Research; Parkinson Society Canada; Québec Consortium for Drug Discovery","keywords":"Organoid; Midbrain; Induced pluripotent stem cell; Human Induced Pluripotent Stem Cells; Human brain; Biology; Neuroscience; Computational biology; Workflow; Substantia nigra; Cell biology; Computer science; Embryonic stem cell; Genetics; Central nervous system; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009455259,0.0001214673,0.0001607967,0.0001312293,0.00005617381,0.0000245469,0.0002038986,0.0002585178,0.00009897479],"category_scores_gemma":[0.0003710947,0.0001239352,0.00005407116,0.0006248698,0.00007877917,0.000002963597,0.0002443418,0.0001658247,0.00002454669],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003072457,"about_ca_system_score_gemma":0.0001202256,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000009592849,"about_ca_topic_score_gemma":0.0000416063,"domain_scores_codex":[0.9981791,0.0007492974,0.0002079284,0.000464219,0.0001015791,0.0002978654],"domain_scores_gemma":[0.9993007,0.00002000889,0.00003933055,0.0004678886,0.0001162003,0.00005593591],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000009753105,0.00004976713,0.0024805,0.00001049803,0.00001588056,0.00001258309,0.00001999876,0.000006628621,0.9411117,0.000009314379,0.001291247,0.05498216],"study_design_scores_gemma":[0.0003911329,0.00003980457,0.001147485,0.000005450065,0.000005091776,0.00002835141,0.00005770854,0.000434279,0.9490186,0.00007457463,0.0486641,0.0001334446],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.902471,0.00419811,0.09041271,0.001603157,0.000230673,0.000175056,0.00001053772,0.00002570535,0.000873053],"genre_scores_gemma":[0.5916756,0.001352511,0.3896248,0.0005057704,0.0003325433,0.0001031737,0.0006699943,0.00007723473,0.01565833],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3107954,"threshold_uncertainty_score":0.505393,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02813767643889641,"score_gpt":0.3576255175093162,"score_spread":0.3294878410704198,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}