{"id":"W3186137940","doi":"10.1016/j.ymeth.2021.07.008","title":"Microfabricated disk technology: Rapid scale up in midbrain organoid generation","year":2021,"lang":"en","type":"article","venue":"Methods","topic":"Pluripotent Stem Cells Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":22,"is_retracted":false,"has_abstract":true,"ca_institutions":"Montreal Neurological Institute and Hospital; McGill University","funders":"Parkinson Canada; Canadian Institutes of Health Research; Parkinson Society Canada; Québec Consortium for Drug Discovery","keywords":"Organoid; Midbrain; Induced pluripotent stem cell; Human Induced Pluripotent Stem Cells; Human brain; Biology; Neuroscience; Computational biology; Workflow; Substantia nigra; Cell biology; Computer science; Embryonic stem cell; Genetics; Central nervous system; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007101321,0.000838404,0.000539919,0.0008527056,0.0004090419,0.0008455995,0.001069381,0.0008340148,0.002440968],"category_scores_gemma":[0.001074183,0.0004769151,0.0006261894,0.0005015203,0.0003603984,0.0005613415,0.0009262128,0.0009111449,0.002714682],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005147557,"about_ca_system_score_gemma":0.0003902962,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000991589,"about_ca_topic_score_gemma":0.002085316,"domain_scores_codex":[0.9992016,0.00007928628,0.00005814893,0.0001913726,0.0004038914,0.00006573666],"domain_scores_gemma":[0.9994604,0.0001595239,0.00008597573,0.0001223395,0.0001127049,0.00005904722],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000409967,0.00005003304,0.0002938292,0.0002012716,0.00001408034,0.0001631331,0.0001237191,0.0006378665,0.9589189,0.0005650845,0.001241635,0.03774944],"study_design_scores_gemma":[0.00001405454,0.0001618339,0.001421724,0.00002400669,0.00002774098,0.0006284178,0.00005335696,0.004204302,0.9607379,0.0003001182,0.03238421,0.00004228381],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"methods","genre_gemma":"methods","genre_scores_codex":[0.169118,0.01149864,0.7984166,0.0007751654,0.0006459124,0.00098114,0.001963681,0.00585688,0.01074392],"genre_scores_gemma":[0.1933457,0.005833312,0.7871259,0.000305648,0.00008183729,0.001067065,0.00211853,0.00061505,0.009506976],"genre_candidate":"methods","genre_consensus":"methods","teacher_disagreement_score":0.002440968,"threshold_uncertainty_score":0.008165836,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02813767643889641,"score_gpt":0.3576255175093162,"score_spread":0.3294878410704198,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}