{"id":"W3186174041","doi":"10.3389/ffunb.2021.683414","title":"Systematic Prediction of Antifungal Drug Synergy by Chemogenomic Screening in Saccharomyces cerevisiae","year":2021,"lang":"en","type":"article","venue":"Frontiers in Fungal Biology","topic":"Microbial Natural Products and Biosynthesis","field":"Medicine","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; University of British Columbia","funders":"Canada Research Chairs","keywords":"Antifungal; Saccharomyces cerevisiae; Antifungal drug; Antifungal drugs; Drug; Computational biology; Pharmacology; Medicine; Biology; Microbiology; Yeast; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007711878,0.0009339997,0.001180243,0.00111589,0.0002259607,0.0009772596,0.0004328074,0.0004445386,0.0004079939],"category_scores_gemma":[0.001750623,0.0002882979,0.0008201529,0.001230131,0.0002742266,0.0003484321,0.0004535386,0.0004277953,0.0002211537],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005653668,"about_ca_system_score_gemma":0.0007139198,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003889807,"about_ca_topic_score_gemma":0.003742479,"domain_scores_codex":[0.9995738,0.00007825372,0.00005269593,0.0001369561,0.0001251052,0.000033195],"domain_scores_gemma":[0.9992099,0.000425554,0.0001582999,0.00005803158,0.00008924167,0.00005898695],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001708625,0.0008138708,0.09579674,0.0008752352,0.0004830181,0.0005195658,0.00008046486,0.231588,0.6064616,0.0009425381,0.001039219,0.059691],"study_design_scores_gemma":[0.00008672033,0.001227801,0.03357426,0.00003495908,0.0002617573,0.0002280233,0.0001414948,0.7024013,0.259303,0.0009699743,0.001684412,0.0000862349],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9758455,0.001198019,0.0170312,0.0001268449,0.00001807427,0.00007775607,0.004351566,0.0006485938,0.0007024739],"genre_scores_gemma":[0.9679772,0.0008777555,0.02627531,0.00004945093,0.000006166579,0.00005773102,0.004513184,0.00004942991,0.0001937538],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003889807,"threshold_uncertainty_score":0.007734299,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007977616757350274,"score_gpt":0.2166991381623847,"score_spread":0.2087215214050344,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}