{"id":"W3186188872","doi":"10.1186/s12974-021-02373-y","title":"MicroRNA-210 regulates the metabolic and inflammatory status of primary human astrocytes","year":2022,"lang":"en","type":"article","venue":"Journal of Neuroinflammation","topic":"MicroRNA in disease regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":36,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University Health Centre; Queen's University; McGill University; Montreal Neurological Institute and Hospital","funders":"International Progressive MS Alliance","keywords":"Astrocyte; Biology; Cell biology; microRNA; Microglia; Downregulation and upregulation; Human brain; Gene knockdown; Inflammation; Pathology; Immunology; Neuroscience; Central nervous system; Cell culture; Medicine; Biochemistry; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003625165,0.00009530822,0.0001530832,0.00009637958,0.0001561328,0.00002004709,0.000157751,0.00003146375,0.00001761831],"category_scores_gemma":[0.0000691319,0.00007974332,0.00009712817,0.00007890284,0.00007788814,0.00001662418,0.0001412278,0.0001317154,2.851549e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000255212,"about_ca_system_score_gemma":0.0001168287,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000002534912,"about_ca_topic_score_gemma":0.000002018238,"domain_scores_codex":[0.99884,0.000197583,0.0004680181,0.0001075069,0.0002496606,0.0001372294],"domain_scores_gemma":[0.9988226,0.00002258188,0.0007619656,0.0001948131,0.0001405204,0.00005750377],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001237629,0.00002325114,0.002417416,0.00002591514,0.00004868468,0.000003343076,0.00009209603,0.001047307,0.9941149,0.000152242,0.0003362491,0.001614873],"study_design_scores_gemma":[0.000578377,0.0002308027,0.2747585,0.000009725578,0.00006214804,0.0001675245,0.00008147017,0.00004281232,0.7066095,0.0001410078,0.0172405,0.00007766125],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9966335,0.00289389,0.00003463568,0.0001038788,0.00008922259,0.0001365658,0.000009616992,0.000003096524,0.00009557189],"genre_scores_gemma":[0.9992511,0.0002513951,0.0002065161,0.00002355928,0.0001711075,0.000004066733,0.00002963797,0.00001557156,0.00004708114],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2875054,"threshold_uncertainty_score":0.3251838,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008592225958644496,"score_gpt":0.2260174504852615,"score_spread":0.217425224526617,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}