{"id":"W3186200384","doi":"10.3390/ph14070697","title":"Albumin Nanoparticle Formulation for Heart-Targeted Drug Delivery: In Vivo Assessment of Congestive Heart Failure","year":2021,"lang":"en","type":"article","venue":"Pharmaceuticals","topic":"Protein Interaction Studies and Fluorescence Analysis","field":"Biochemistry, Genetics and Molecular Biology","cited_by":15,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"Canadian Institutes of Health Research; McGill University Health Centre; Natural Sciences and Engineering Research Council of Canada; McGill University","keywords":"Milrinone; Heart failure; Inotrope; Medicine; Ejection fraction; Pharmacokinetics; Pharmacology; Cardiac function curve; In vivo; Cardiology; Contractility; Internal medicine; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002410468,0.00009661836,0.0002034193,0.00003304676,0.0000539387,0.00001288616,0.00005341322,0.00004802689,0.0001239327],"category_scores_gemma":[0.000111416,0.00009557045,0.0001225119,0.0001449454,0.00003129306,0.00001016971,0.00006653084,0.00006469349,0.000002598764],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002466458,"about_ca_system_score_gemma":0.00007086767,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002426306,"about_ca_topic_score_gemma":0.00009843207,"domain_scores_codex":[0.9990764,0.00007700174,0.0002679421,0.0002532152,0.0001062851,0.0002191428],"domain_scores_gemma":[0.9994118,0.00006188283,0.00005772435,0.0001449088,0.0002594056,0.00006426156],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006951583,0.0001148275,0.01896447,0.00002350867,0.00008486936,8.83615e-7,0.00003123634,0.0001160063,0.9762033,0.0001322841,0.004052793,0.0002062732],"study_design_scores_gemma":[0.0007386598,0.00005333461,0.003101059,0.00001778452,0.0000446747,0.000002290346,0.0002193968,0.005920082,0.9450064,0.00005800567,0.04473702,0.0001012514],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9945118,0.0007775238,0.001442043,0.002766672,0.00006979765,0.0002976671,0.00005341034,0.000006259859,0.00007478719],"genre_scores_gemma":[0.9955512,0.0001035219,0.003456127,0.0005993376,0.00005336825,0.00008692605,0.0000375159,0.000009026541,0.0001029857],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04068423,"threshold_uncertainty_score":0.389725,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02496631393392698,"score_gpt":0.3703908728966134,"score_spread":0.3454245589626864,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}