{"id":"W3186223954","doi":"10.1080/10428194.2021.1953006","title":"Gut bacterial gene changes following pegaspargase treatment in pediatric patients with acute lymphoblastic leukemia","year":2021,"lang":"en","type":"article","venue":"Leukemia & lymphoma/Leukemia and lymphoma","topic":"Childhood Cancer Survivors' Quality of Life","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Izaak Walton Killam Health Centre; Dalhousie University","funders":"IWK Health Centre; Nova Scotia Health Research Foundation","keywords":"Asparaginase; Asparagine; Glutamine; Lymphoblastic Leukemia; Asparagine synthetase; Gut microbiome; Gene; Medicine; Microbiome; Biology; Amino acid; Gut flora; Microbiology; Leukemia; Biochemistry; Internal medicine; Bioinformatics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008647342,0.0001503611,0.0003237675,0.0003874824,0.0002094783,0.000337669,0.00007997399,0.0002201703,0.0007266406],"category_scores_gemma":[0.0003837446,0.00008772733,0.0001785883,0.0007704367,0.0001921392,0.0001396874,0.0001641311,0.00034219,0.0001019092],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003934319,"about_ca_system_score_gemma":0.0001662758,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00157016,"about_ca_topic_score_gemma":0.001866186,"domain_scores_codex":[0.9998479,0.00002828221,0.00001164742,0.00003118844,0.00003211467,0.00004888876],"domain_scores_gemma":[0.9998222,0.00003910255,0.00007681335,0.000006972494,0.00001957286,0.00003549221],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.004038254,0.000143304,0.9227353,0.0001123416,0.00009338027,0.002510721,0.000464348,0.0003367555,0.04680209,0.00007578379,0.000411212,0.02227651],"study_design_scores_gemma":[0.00001594027,0.0004792067,0.9908343,0.00001061592,0.00006330999,0.001594332,0.0005412973,0.0002339865,0.005258087,0.00005043389,0.0009129198,0.000005615465],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9987436,0.0005043584,0.00009391009,0.0000487031,0.000005224862,0.000007008923,0.0003428762,0.000005102033,0.0002491491],"genre_scores_gemma":[0.9986243,0.0003975673,0.0002176155,0.00006012062,0.000005863275,0.0000139727,0.0004313392,0.00000319532,0.0002460759],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00157016,"threshold_uncertainty_score":0.003122032,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01038339087494897,"score_gpt":0.2417552693224191,"score_spread":0.2313718784474701,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}