{"id":"W3186239990","doi":"10.1016/j.jmb.2021.167152","title":"Transient Tertiary Structures of Disordered Dynein Intermediate Chain Regulate its Interactions with Multiple Partners","year":2021,"lang":"en","type":"article","venue":"Journal of Molecular Biology","topic":"Microtubule and mitosis dynamics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":11,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of British Columbia","funders":"Natural Sciences and Engineering Research Council of Canada; M.J. Murdock Charitable Trust; Health Effects Institute; Oregon State University; National Institutes of Health; National Science Foundation","keywords":"Dynein; Dynactin; Biophysics; Intrinsically disordered proteins; Molecular dynamics; Chemistry; Coiled coil; Linker; Binding domain; Protein structure; Binding site; Cell biology; Biology; Microtubule; Biochemistry; Computer science; Computational chemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001105261,0.0001291781,0.0001962191,0.0001470068,0.0002997489,0.000450748,0.0002834274,0.0002110428,0.001508827],"category_scores_gemma":[0.0003208998,0.0001588936,0.0001340966,0.0001012362,0.0003128958,0.0004742795,0.0002902712,0.0005044763,0.0003034148],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005890162,"about_ca_system_score_gemma":0.0001750839,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003317502,"about_ca_topic_score_gemma":0.0005234563,"domain_scores_codex":[0.9999214,0.000008190736,0.000004235449,0.00002237288,0.00001636265,0.00002733627],"domain_scores_gemma":[0.9997246,0.00005955331,0.00006575827,0.00002829334,0.00003022163,0.00009147864],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003012013,0.00004425281,0.0009873773,0.00002622805,0.000005758846,0.0001508347,0.00005382046,0.0003291503,0.9962231,0.0008509391,0.00008501,0.0009424455],"study_design_scores_gemma":[0.00004526111,0.0001106697,0.02034874,0.000007924683,0.00002051429,0.0003312456,0.0001705311,0.01493199,0.9622952,0.0006996529,0.001018718,0.00001953664],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9984548,0.0001752324,0.0008303559,0.00002801903,0.00001081786,0.000003081619,0.00002471829,0.00001986856,0.0004531303],"genre_scores_gemma":[0.9994459,0.0000343724,0.0001493077,0.000009488935,0.000002473357,0.000003040274,0.00004111288,0.000005620083,0.0003086455],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001508827,"threshold_uncertainty_score":0.00504756,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005870679651404422,"score_gpt":0.2652024899340242,"score_spread":0.2593318102826198,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}