{"id":"W3186286798","doi":"10.3390/cancers13143607","title":"Target Heterogeneity in Oncology: The Best Predictor for Differential Response to Radioligand Therapy in Neuroendocrine Tumors and Prostate Cancer","year":2021,"lang":"en","type":"review","venue":"Cancers","topic":"Prostate Cancer Treatment and Research","field":"Medicine","cited_by":31,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"","keywords":"Prostate cancer; Medicine; Radionuclide therapy; Neuroendocrine tumors; Oncology; Cancer; Radioligand; Targeted therapy; Tumor heterogeneity; Internal medicine; Cancer research; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007160007,0.0007238342,0.002073606,0.001848108,0.0001436873,0.0008994722,0.0007328839,0.0009978908,0.001871305],"category_scores_gemma":[0.0009705709,0.0002660877,0.0007343437,0.001698982,0.0004053772,0.0008102225,0.0003732505,0.001463854,0.0007128267],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007353121,"about_ca_system_score_gemma":0.0008000264,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001176168,"about_ca_topic_score_gemma":0.002340544,"domain_scores_codex":[0.9998041,0.00005372033,0.00003303537,0.00003629042,0.00005803775,0.00001488667],"domain_scores_gemma":[0.9996359,0.0002235452,0.00005880783,0.000005786692,0.00006114207,0.00001488813],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001755819,0.00007326667,0.0007658584,0.02843328,0.0003627391,0.0001433798,0.00004863658,0.0004310686,0.0009411895,0.002392576,0.01500905,0.9512235],"study_design_scores_gemma":[0.0001591448,0.0007594647,0.01094864,0.03340877,0.002400656,0.003735404,0.0002226008,0.0009347951,0.001553786,0.006304066,0.9394596,0.00011304],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00009316007,0.9994562,0.000042367,0.0001424248,0.00004905499,0.000002829604,0.00001057032,0.000001955206,0.000201406],"genre_scores_gemma":[0.001380441,0.9980046,0.0001405854,0.0001614153,0.00009810225,0.000007066825,0.00002547574,8.421007e-7,0.0001815472],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002073606,"threshold_uncertainty_score":0.006260157,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0724530169037287,"score_gpt":0.4177171710943418,"score_spread":0.3452641541906131,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}