{"id":"W3186288373","doi":"10.1128/mbio.01656-21","title":"Cation and Anion Channelrhodopsins: Sequence Motifs and Taxonomic Distribution","year":2021,"lang":"en","type":"article","venue":"mBio","topic":"Photoreceptor and optogenetics research","field":"Neuroscience","cited_by":38,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta; University of Guelph","funders":"National Institute of Neurological Disorders and Stroke; National Institute of General Medical Sciences; Agricultural Science and Technology Innovation Program; Natural Sciences and Engineering Research Council of Canada; Office of Science; National Institutes of Health; Government of Canada; Universities Space Research Association; Joint Genome Institute; Welch Foundation; U.S. Department of Energy","keywords":"Channelrhodopsin; Chlamydomonas; Chlamydomonas reinhardtii; Metagenomics; Biology; Optogenetics; Transmembrane domain; Context (archaeology); Rhodopsin; Computational biology; Genetics; Gene; Biochemistry; Retinal","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002637878,0.0001530646,0.0001964883,0.0010098,0.0003644865,0.0004467199,0.0002327352,0.0003425036,0.001308747],"category_scores_gemma":[0.000430171,0.00009345697,0.0001375127,0.0007430384,0.0002569709,0.0004926346,0.0003340998,0.0002512366,0.0005964121],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002668982,"about_ca_system_score_gemma":0.0002978014,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002900996,"about_ca_topic_score_gemma":0.003291069,"domain_scores_codex":[0.9997653,0.00002989965,0.00002997045,0.00009660915,0.00004757059,0.00003071397],"domain_scores_gemma":[0.9997446,0.00003827757,0.0001044011,0.0000193615,0.00004908098,0.00004421631],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0001797008,0.00002252873,0.033962,0.0001348157,0.00001320223,0.00008373801,0.000326645,0.00009129002,0.938907,0.0002532291,0.00009296246,0.0259329],"study_design_scores_gemma":[0.00001501948,0.0002815287,0.8701956,0.00009539915,0.00006069962,0.002185956,0.001032491,0.001406329,0.1082414,0.0009173061,0.0155307,0.0000374973],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9870743,0.004750294,0.004935489,0.0001286797,0.00001310117,0.00002185768,0.001087788,0.00003919829,0.001949296],"genre_scores_gemma":[0.9843296,0.002286214,0.009468208,0.00009950628,0.00001600667,0.00002869051,0.00250373,0.00002155209,0.00124644],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002900996,"threshold_uncertainty_score":0.005768239,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09780192048157847,"score_gpt":0.3157809176978073,"score_spread":0.2179789972162288,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}