{"id":"W3186288373","doi":"10.1128/mbio.01656-21","title":"Cation and Anion Channelrhodopsins: Sequence Motifs and Taxonomic Distribution","year":2021,"lang":"en","type":"article","venue":"mBio","topic":"Photoreceptor and optogenetics research","field":"Neuroscience","cited_by":38,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta; University of Guelph","funders":"National Institute of Neurological Disorders and Stroke; National Institute of General Medical Sciences; Agricultural Science and Technology Innovation Program; Natural Sciences and Engineering Research Council of Canada; Office of Science; National Institutes of Health; Government of Canada; Universities Space Research Association; Joint Genome Institute; Welch Foundation; U.S. Department of Energy","keywords":"Channelrhodopsin; Chlamydomonas; Chlamydomonas reinhardtii; Metagenomics; Biology; Optogenetics; Transmembrane domain; Context (archaeology); Rhodopsin; Computational biology; Genetics; Gene; Biochemistry; Retinal","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009285184,0.00005803778,0.00005912646,0.00001937892,0.0001191815,0.00008321862,0.0000518703,0.00003822219,0.00002845448],"category_scores_gemma":[0.0002338471,0.00005918675,0.00001023859,0.0001237869,0.00009427074,0.0000919616,0.00007746561,0.00006936989,0.00001551426],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004390038,"about_ca_system_score_gemma":0.00003695041,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003392594,"about_ca_topic_score_gemma":0.00001554971,"domain_scores_codex":[0.9993398,0.00006897156,0.00007261601,0.0002695299,0.0001037151,0.0001453944],"domain_scores_gemma":[0.999715,0.0000475847,0.00002033931,0.0001129896,0.00003208061,0.00007197184],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000005708548,0.00001574063,0.001410281,0.00001160756,6.722668e-7,0.000005460887,0.00007165061,0.000002648616,0.9932352,0.0006389458,0.0001305944,0.004471542],"study_design_scores_gemma":[0.0001441381,0.00003097288,0.01242286,0.000008808865,0.000002044823,0.00003577147,0.00003166815,0.002775095,0.9796497,0.0003337587,0.004492325,0.00007281602],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9982263,0.0001937325,0.0006629181,0.0002653502,0.0001071127,0.00009707601,0.00008850999,0.00001800938,0.000340993],"genre_scores_gemma":[0.9989113,0.0006596709,0.00007895433,0.00007776239,0.00003515528,0.000009703138,0.00003435457,0.000004904213,0.0001882226],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0135854,"threshold_uncertainty_score":0.2413566,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09780192048157847,"score_gpt":0.3157809176978073,"score_spread":0.2179789972162288,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}