{"id":"W3186328747","doi":"10.1093/cid/ciab629","title":"The Adjuvanted Recombinant Zoster Vaccine Confers Long-Term Protection Against Herpes Zoster: Interim Results of an Extension Study of the Pivotal Phase 3 Clinical Trials ZOE-50 and ZOE-70","year":2021,"lang":"en","type":"article","venue":"Clinical Infectious Diseases","topic":"Herpesvirus Infections and Treatments","field":"Medicine","cited_by":93,"is_retracted":false,"has_abstract":true,"ca_institutions":"Island Health; Université Laval","funders":"European and Developing Countries Clinical Trials Partnership; Else Kröner-Fresenius-Stiftung; Deutsche Forschungsgemeinschaft; Deutsches Zentrum für Infektionsforschung; Biogen; Sanofi; Pfizer","keywords":"Medicine; Vaccination; Interim analysis; Vaccine efficacy; Confidence interval; Immune system; Immunology; Clinical trial; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.01479344,0.0009272837,0.00111258,0.0003522579,0.0003375988,0.0008157647,0.0005297837,0.0007345834,0.001707167],"category_scores_gemma":[0.006481397,0.0003204452,0.001710924,0.0003035971,0.0004511829,0.0008572739,0.0006131636,0.001307932,0.0004288191],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004271114,"about_ca_system_score_gemma":0.001086184,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005131101,"about_ca_topic_score_gemma":0.0006974071,"domain_scores_codex":[0.9976979,0.001308287,0.0001327822,0.0002213538,0.0002651257,0.0003745924],"domain_scores_gemma":[0.9952349,0.001430438,0.001410335,0.0005987347,0.000570788,0.0007549076],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.7127247,0.01622406,0.1395749,0.0008311447,0.004680661,0.0003060999,0.000599964,0.001879998,0.02037139,0.0003483006,0.003878312,0.09858051],"study_design_scores_gemma":[0.07929455,0.5092326,0.3856572,0.0001735686,0.005787846,0.0006308809,0.0001771031,0.001325709,0.009826533,0.0003388135,0.007481633,0.0000734624],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9939287,0.002321297,0.0007340762,0.0001605024,0.00007171715,0.0005307647,0.001392659,0.00003013299,0.0008302556],"genre_scores_gemma":[0.9941654,0.0006052242,0.001035074,0.0002198902,0.0001030419,0.0004825047,0.002565404,0.00001070361,0.0008127356],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01479344,"threshold_uncertainty_score":0.0782361,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1645228239973803,"score_gpt":0.4817775912955929,"score_spread":0.3172547672982126,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}