{"id":"W3186360607","doi":"10.1016/j.molmed.2021.07.007","title":"Prospective antibacterial inhibition of c-type cytochrome synthesis","year":2021,"lang":"en","type":"article","venue":"Trends in Molecular Medicine","topic":"Cancer therapeutics and mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":3,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"Nature Conservancy of Canada","keywords":"Cytochrome; ATP synthase; In vitro; Bacteria; Cytochrome c; Antibacterial activity; Microbiology; Biology; Biochemistry; Chemistry; Enzyme; Mitochondrion; Genetics","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004512756,0.0003804818,0.0002232662,0.0001667299,0.0001858217,0.0006238376,0.0002634163,0.0004707239,0.003844461],"category_scores_gemma":[0.0002859396,0.00009462219,0.0002569244,0.0001159227,0.0002497423,0.0003290068,0.0002117216,0.0007358606,0.0005939065],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004789714,"about_ca_system_score_gemma":0.0004995334,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002112836,"about_ca_topic_score_gemma":0.0003857143,"domain_scores_codex":[0.9998222,0.00003642583,0.00001301081,0.00002813803,0.00004969636,0.00005060848],"domain_scores_gemma":[0.9998333,0.00003258252,0.00002828163,0.0000191215,0.00004621989,0.00004044942],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00132757,0.0001873295,0.0007597606,0.0002740684,0.00002688111,0.0001436948,0.00001513837,0.0001186352,0.9606304,0.005030672,0.00105546,0.0304304],"study_design_scores_gemma":[0.0001751057,0.002626319,0.004509666,0.00005628229,0.00005907042,0.0007534561,0.00002815281,0.0009177048,0.9666504,0.001552817,0.02265968,0.00001126671],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8280497,0.1027863,0.02121624,0.007183918,0.00222605,0.0002586163,0.000897174,0.0004189999,0.03696297],"genre_scores_gemma":[0.9711494,0.01451063,0.003495919,0.0005971109,0.0002672262,0.00005476198,0.0003901474,0.00002225289,0.009512572],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003844461,"threshold_uncertainty_score":0.01286101,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01301133790274203,"score_gpt":0.2836813854645568,"score_spread":0.2706700475618148,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}