{"id":"W3186390505","doi":"10.1038/s41467-021-24677-6","title":"Lineage-defined leiomyosarcoma subtypes emerge years before diagnosis and determine patient survival","year":2021,"lang":"en","type":"article","venue":"Nature Communications","topic":"Sarcoma Diagnosis and Treatment","field":"Medicine","cited_by":64,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ontario Institute for Cancer Research; Princess Margaret Cancer Centre; SickKids Foundation; University of Toronto; University Health Network; Lunenfeld-Tanenbaum Research Institute; Mount Sinai Hospital; Hospital for Sick Children","funders":"Ontario Ministry of Research and Innovation; Canadian Institutes of Health Research; Hospital for Sick Children; University of Toronto; St. Baldrick's Foundation","keywords":"Biology; Subtyping; Homologous recombination; Leiomyosarcoma; Genome; Somatic evolution in cancer; Transcriptome; Lineage (genetic); CRISPR; Phylogenetic tree; Cancer research; Computational biology; Bioinformatics; Genetics; Gene; Pathology; Medicine; Gene expression","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001758597,0.00009068765,0.0001804854,0.000349558,0.0001545467,0.0002973758,0.00008158838,0.0001825526,0.001702475],"category_scores_gemma":[0.000601289,0.00007823134,0.00009866256,0.0002509091,0.0001064692,0.0002026657,0.0002176189,0.0002474227,0.0004119396],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001698732,"about_ca_system_score_gemma":0.0001214415,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005665897,"about_ca_topic_score_gemma":0.001289257,"domain_scores_codex":[0.999898,0.00001585208,0.000005906492,0.00003378082,0.00001672381,0.00002977675],"domain_scores_gemma":[0.9996885,0.00008344523,0.0001226856,0.00001967392,0.00003047557,0.00005529392],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0003800167,0.00001883363,0.9455442,0.0000269996,0.00004204903,0.0002247566,0.000201543,0.0003096573,0.03346851,0.0002518418,0.0005564164,0.01897519],"study_design_scores_gemma":[0.000003427572,0.00005385474,0.9934978,0.00001185146,0.00002287052,0.0005733854,0.0002062352,0.0004134458,0.002921626,0.0002971951,0.001994365,0.000003970354],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.997461,0.0007730128,0.0003699117,0.00007288635,0.000003879052,0.00000361596,0.0005844494,0.00001498271,0.0007162682],"genre_scores_gemma":[0.9975554,0.0004115604,0.0002429875,0.00006105928,0.000006607358,0.000007193948,0.001169332,0.000008848075,0.0005370823],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001702475,"threshold_uncertainty_score":0.005695403,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02786700284964891,"score_gpt":0.3065186559412287,"score_spread":0.2786516530915797,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}