{"id":"W3186393640","doi":"10.1038/s41467-021-26151-9","title":"Germline determinants of humoral immune response to HPV-16 protect against oropharyngeal cancer","year":2021,"lang":"en","type":"article","venue":"Nature Communications","topic":"Head and Neck Cancer Studies","field":"Medicine","cited_by":42,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Sinai Health System; Lunenfeld-Tanenbaum Research Institute","funders":"National Institute of Dental and Craniofacial Research; National Cancer Institute; Medical Research Council; Associazione Italiana per la Ricerca sul Cancro; Princess Margaret Hospital Foundation; World Health Organization; European Commission; University of Pittsburgh; National Institute for Health and Care Research; Compagnia di San Paolo; Centre International de Recherche sur le Cancer; Canadian Cancer Society Research Institute; U.S. Department of Health and Human Services; National Institutes of Health; Cancer Research UK","keywords":"Immune system; Germline; Immunology; Human leukocyte antigen; Cancer; Genetic predisposition; Biology; Serology; Capsid; Haplotype; Antibody; Virology; Virus; Genetics; Gene; Allele; Antigen","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003101433,0.0001414505,0.0005105986,0.0001061447,0.0002262983,0.000008295103,0.0003949747,0.0001687012,0.00009261021],"category_scores_gemma":[0.0007944161,0.000125037,0.0001199476,0.0005911915,0.0001198638,0.00004423947,0.00045443,0.0007283996,0.00001250426],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001756044,"about_ca_system_score_gemma":0.0005803535,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001044968,"about_ca_topic_score_gemma":0.001613126,"domain_scores_codex":[0.9987814,0.0002109004,0.0003763576,0.0002052621,0.0002121781,0.0002138526],"domain_scores_gemma":[0.9972842,0.000208275,0.000104192,0.00173862,0.0005507614,0.0001139517],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.004233534,0.001534928,0.06337782,0.0004244587,0.00044352,0.000146502,0.004420759,0.000007720652,0.7947418,0.0003072246,0.01620264,0.1141591],"study_design_scores_gemma":[0.002021409,0.0003747604,0.7277504,0.000696356,0.0001438857,0.00004139622,0.0005409563,0.00008981811,0.1324262,0.00001858399,0.1356256,0.000270607],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9232265,0.0480202,0.00000660455,0.02430263,0.0001774614,0.0005868964,0.0001210525,0.00004782126,0.00351078],"genre_scores_gemma":[0.9904526,0.003035537,0.003093232,0.001689077,0.00006887461,0.0002272015,0.00005120038,0.00002435557,0.001357866],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.6643726,"threshold_uncertainty_score":0.5098862,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03930495749599747,"score_gpt":0.3860100709190241,"score_spread":0.3467051134230266,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}