{"id":"W3186393640","doi":"10.1038/s41467-021-26151-9","title":"Germline determinants of humoral immune response to HPV-16 protect against oropharyngeal cancer","year":2021,"lang":"en","type":"article","venue":"Nature Communications","topic":"Head and Neck Cancer Studies","field":"Medicine","cited_by":42,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Sinai Health System; Lunenfeld-Tanenbaum Research Institute","funders":"National Institute of Dental and Craniofacial Research; National Cancer Institute; Medical Research Council; Associazione Italiana per la Ricerca sul Cancro; Princess Margaret Hospital Foundation; World Health Organization; European Commission; University of Pittsburgh; National Institute for Health and Care Research; Compagnia di San Paolo; Centre International de Recherche sur le Cancer; Canadian Cancer Society Research Institute; U.S. Department of Health and Human Services; National Institutes of Health; Cancer Research UK","keywords":"Immune system; Germline; Immunology; Human leukocyte antigen; Cancer; Genetic predisposition; Biology; Serology; Capsid; Haplotype; Antibody; Virology; Virus; Genetics; Gene; Allele; Antigen","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002960618,0.0001306225,0.0001423695,0.0002522678,0.0001200773,0.0002524374,0.00009328415,0.0001619386,0.001998477],"category_scores_gemma":[0.001011581,0.00009707818,0.0001116544,0.0001799472,0.0001716015,0.0001090507,0.0001411847,0.0001774737,0.0001595744],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00008568868,"about_ca_system_score_gemma":0.0001097302,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000706612,"about_ca_topic_score_gemma":0.00067991,"domain_scores_codex":[0.999874,0.00003786583,0.000006993873,0.00002954734,0.00001880134,0.00003268004],"domain_scores_gemma":[0.9995034,0.0001462801,0.0001502237,0.00005729809,0.0000416707,0.000101127],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0008028141,0.0001024271,0.9663064,0.00002520873,0.00008253542,0.0001294599,0.00009932664,0.00007913772,0.02466219,0.00006950312,0.0001083406,0.007532659],"study_design_scores_gemma":[0.0000153333,0.0004254875,0.9969214,0.000004331341,0.00003613609,0.0003372662,0.00005342923,0.00007599591,0.001823179,0.00004481087,0.0002610239,0.000001588211],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9995033,0.0001186493,0.00003319835,0.0000111306,0.000002282261,0.00000171258,0.00002508325,0.00000274734,0.0003019188],"genre_scores_gemma":[0.9997746,0.00003625905,0.00002459858,0.000008739281,0.000003757715,9.086596e-7,0.000030495,8.703246e-7,0.0001198356],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001998477,"threshold_uncertainty_score":0.006685615,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03930495749599747,"score_gpt":0.3860100709190241,"score_spread":0.3467051134230266,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}