{"id":"W3186401135","doi":"10.1016/j.celrep.2021.109418","title":"Whole-genome sequencing of H3K4me3 and DNA methylation in human sperm reveals regions of overlap linked to fertility and development","year":2021,"lang":"en","type":"article","venue":"Cell Reports","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":45,"is_retracted":false,"has_abstract":true,"ca_institutions":"CReATe Fertility Centre; University of Toronto; McGill University Health Centre; North York General Hospital; Concordia University; National Research Council Canada; McGill University","funders":"Canadian Institutes of Health Research; McGill University","keywords":"H3K4me3; Biology; Epigenetics; DNA methylation; Sperm; Chromatin; Genetics; Reprogramming; Histone; Population; Transcriptome; Epigenomics; Gene; Gene expression; Promoter; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004085468,0.00007957881,0.0001642279,0.00004683435,0.00003117605,0.000006541373,0.00002327438,0.00009188824,0.000003525969],"category_scores_gemma":[0.0001167319,0.0000859833,0.00002225567,0.0000798859,0.00003049511,0.000002965854,0.00008148822,0.0000377826,9.143092e-8],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002079124,"about_ca_system_score_gemma":0.0001112247,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000190242,"about_ca_topic_score_gemma":0.00005484435,"domain_scores_codex":[0.9990348,0.00004657395,0.0004460342,0.0002845866,0.00009202034,0.00009594617],"domain_scores_gemma":[0.9993868,0.00001106824,0.0001797922,0.0002443554,0.0001198337,0.00005816588],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000006877393,0.0000235819,0.03325077,0.00006900034,0.000007042301,0.00001172312,0.0003568463,0.00006437747,0.9655427,0.000005076537,0.000001529186,0.0006605102],"study_design_scores_gemma":[0.00008077824,0.00003399944,0.342237,0.00001804622,0.000004871327,0.000002608378,0.00006730045,0.00000188145,0.6565685,0.0002283834,0.0006974742,0.00005913753],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9966457,0.001740649,0.0008628864,0.00001877984,0.00002587422,0.000138639,0.000003154842,0.000002085141,0.0005622543],"genre_scores_gemma":[0.9970133,0.00006265604,0.002521492,0.00001340752,0.00001140373,0.00000474045,0.0001033808,0.000007713605,0.0002618655],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3089863,"threshold_uncertainty_score":0.3506297,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02680662641164407,"score_gpt":0.2723429372890402,"score_spread":0.2455363108773961,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}