{"id":"W3186401135","doi":"10.1016/j.celrep.2021.109418","title":"Whole-genome sequencing of H3K4me3 and DNA methylation in human sperm reveals regions of overlap linked to fertility and development","year":2021,"lang":"en","type":"article","venue":"Cell Reports","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":45,"is_retracted":false,"has_abstract":true,"ca_institutions":"CReATe Fertility Centre; University of Toronto; McGill University Health Centre; North York General Hospital; Concordia University; National Research Council Canada; McGill University","funders":"Canadian Institutes of Health Research; McGill University","keywords":"H3K4me3; Biology; Epigenetics; DNA methylation; Sperm; Chromatin; Genetics; Reprogramming; Histone; Population; Transcriptome; Epigenomics; Gene; Gene expression; Promoter; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000145514,0.0001440465,0.0002202035,0.0003648559,0.0002538752,0.0002520353,0.0001316642,0.0002242083,0.001874653],"category_scores_gemma":[0.0002964764,0.0001301799,0.000204201,0.000496757,0.0001684343,0.00009145588,0.0002986885,0.0001842341,0.0003037291],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001384759,"about_ca_system_score_gemma":0.0002160565,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002283266,"about_ca_topic_score_gemma":0.00556071,"domain_scores_codex":[0.9999077,0.00001195069,0.000004669624,0.0000383853,0.00002209053,0.00001520326],"domain_scores_gemma":[0.9999244,0.00002062539,0.00001890661,0.00001079052,0.00001382425,0.0000114352],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0006054909,0.00003573781,0.1862502,0.0001940278,0.0003642935,0.0002411547,0.0003693699,0.001047265,0.7598191,0.0003754365,0.0006661012,0.05003183],"study_design_scores_gemma":[0.00002224298,0.0002618841,0.8598794,0.00001909446,0.0002063965,0.001261459,0.0002435447,0.001773194,0.1276536,0.0006119725,0.008047584,0.0000195879],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9915547,0.001703881,0.003404741,0.00006297776,0.00000656671,0.000008695239,0.002363528,0.00004427871,0.0008505843],"genre_scores_gemma":[0.9930999,0.0006511519,0.001999081,0.00006007621,0.000004766624,0.00001070273,0.002381933,0.00001684011,0.001775506],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002283266,"threshold_uncertainty_score":0.006271362,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02680662641164407,"score_gpt":0.2723429372890402,"score_spread":0.2455363108773961,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}