{"id":"W3186409853","doi":"10.1039/d1dt01653a","title":"Getting a lead on Pb<sup>2+</sup>-amide chelators for <sup>203/212</sup>Pb radiopharmaceuticals","year":2021,"lang":"en","type":"article","venue":"Dalton Transactions","topic":"Radiopharmaceutical Chemistry and Applications","field":"Medicine","cited_by":27,"is_retracted":false,"has_abstract":true,"ca_institutions":"Simon Fraser University; University of British Columbia; TRIUMF","funders":"Canadian Institutes of Health Research; Natural Sciences and Engineering Research Council of Canada; University of British Columbia; Mitacs","keywords":"Chemistry; Chelation; Ligand (biochemistry); Amide; Titration; Metal; Denticity; Potentiometric titration; Metal ions in aqueous solution; Ion; Crystallography; Isomerization; Nuclear magnetic resonance spectroscopy; Nuclear chemistry; Physical chemistry; Crystal structure; Inorganic chemistry; Stereochemistry; Organic chemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.000339288,0.0004610181,0.0006409864,0.0001302196,0.0006561225,0.00007551912,0.0002205873,0.0003500247,0.001558537],"category_scores_gemma":[0.000198875,0.0004722747,0.0005852962,0.0007291826,0.0002252807,0.000175353,0.00001132885,0.001121134,0.000237825],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002589379,"about_ca_system_score_gemma":0.0003140335,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00000852905,"about_ca_topic_score_gemma":0.000001106915,"domain_scores_codex":[0.9969703,0.00008546803,0.0007392892,0.0009005145,0.000470107,0.0008343177],"domain_scores_gemma":[0.9974843,0.0007047348,0.00009670672,0.0007378907,0.0002386845,0.0007376486],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001538116,0.004926931,0.0002893819,0.002703862,0.001927867,0.0003299568,0.002669859,0.0549182,0.8426407,0.004484227,0.009568292,0.07400263],"study_design_scores_gemma":[0.003960579,0.0001407885,0.00007602695,0.0001990065,0.001005918,0.0003375705,0.0008207288,0.07236353,0.6694449,0.0002493128,0.2508652,0.0005364591],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.5492706,0.002802775,0.3549045,0.05859868,0.0005096733,0.004480285,0.001836385,0.001599243,0.02599785],"genre_scores_gemma":[0.9770266,0.0003967376,0.007697352,0.003893047,0.000843729,0.0007927538,0.000361379,0.000126812,0.008861585],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.427756,"threshold_uncertainty_score":0.9997729,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04571520749294482,"score_gpt":0.3478154430446647,"score_spread":0.3021002355517199,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}