{"id":"W3186409853","doi":"10.1039/d1dt01653a","title":"Getting a lead on Pb<sup>2+</sup>-amide chelators for <sup>203/212</sup>Pb radiopharmaceuticals","year":2021,"lang":"en","type":"article","venue":"Dalton Transactions","topic":"Radiopharmaceutical Chemistry and Applications","field":"Medicine","cited_by":27,"is_retracted":false,"has_abstract":true,"ca_institutions":"Simon Fraser University; University of British Columbia; TRIUMF","funders":"Canadian Institutes of Health Research; Natural Sciences and Engineering Research Council of Canada; University of British Columbia; Mitacs","keywords":"Chemistry; Chelation; Ligand (biochemistry); Amide; Titration; Metal; Denticity; Potentiometric titration; Metal ions in aqueous solution; Ion; Crystallography; Isomerization; Nuclear magnetic resonance spectroscopy; Nuclear chemistry; Physical chemistry; Crystal structure; Inorganic chemistry; Stereochemistry; Organic chemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003374308,0.0005947633,0.0003960225,0.0001586211,0.000305535,0.0003633394,0.0003741147,0.0004064171,0.003528822],"category_scores_gemma":[0.0003031578,0.0003048602,0.0002967225,0.000178275,0.0003156117,0.0004274849,0.0004654446,0.0005760954,0.002641385],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002387413,"about_ca_system_score_gemma":0.000428275,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006468922,"about_ca_topic_score_gemma":0.001259895,"domain_scores_codex":[0.9998779,0.0000230026,0.00000802257,0.00002627769,0.00003165025,0.00003312255],"domain_scores_gemma":[0.9998783,0.00001819176,0.00002027423,0.00001573463,0.00004298614,0.00002452202],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003410905,0.00002387403,0.0001926571,0.0002154805,0.000009365412,0.0001773333,0.0001098538,0.0002426791,0.9841173,0.001192787,0.0006158007,0.01276181],"study_design_scores_gemma":[0.00002984326,0.000581423,0.0003721648,0.00001691036,0.00002037875,0.0003161268,0.00003141357,0.0003121874,0.9840283,0.0002358461,0.01404369,0.00001165015],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8187388,0.0104786,0.1188065,0.001944827,0.0004822439,0.0007127303,0.0005893668,0.002551149,0.04569564],"genre_scores_gemma":[0.801424,0.008419557,0.1465137,0.001552675,0.0001223135,0.0003127405,0.0006556454,0.0006727584,0.04032667],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003528822,"threshold_uncertainty_score":0.01180512,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04571520749294482,"score_gpt":0.3478154430446647,"score_spread":0.3021002355517199,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}