{"id":"W3186429039","doi":"10.1038/s41398-021-01490-9","title":"Effects of eight neuropsychiatric copy number variants on human brain structure","year":2021,"lang":"en","type":"article","venue":"Translational Psychiatry","topic":"Genomic variations and chromosomal abnormalities","field":"Biochemistry, Genetics and Molecular Biology","cited_by":47,"is_retracted":false,"has_abstract":true,"ca_institutions":"Montreal Neurological Institute and Hospital; McGill University; Université de Montréal; Mila - Quebec Artificial Intelligence Institute; Centre Hospitalier Universitaire Sainte-Justine","funders":"National Institute of Biomedical Imaging and Bioengineering; National Institute of Mental Health; Institut de Valorisation des Données; Medical Research Council; Fondation Roger de Spoelberch; Centre Hospitalier Universitaire Vaudois; National Institutes of Health; Canada First Research Excellence Fund; U.S. Department of Health and Human Services; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; Simons Foundation Autism Research Initiative; Simons Foundation; Health and Care Research Wales; Wellcome Trust; Fondation Brain Canada; Fondation Leenaards; Canadian Institute for Advanced Research; Canadian Institutes of Health Research; Compute Canada; National Science Foundation","keywords":"Copy-number variation; Schizophrenia (object-oriented programming); Human brain; Psychology; Psychiatry; Medicine; Neuroscience; Genetics; Biology; Gene; Genome","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00003866296,0.0001470892,0.0001322048,0.00003193384,0.0001150373,0.00001391957,0.0001155983,0.000127271,0.0003516418],"category_scores_gemma":[0.00001075818,0.0001475217,0.000120886,0.000135847,0.00003462083,0.00000464406,0.00001443038,0.00009753305,0.0000122087],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00000320323,"about_ca_system_score_gemma":0.0002055008,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000006160835,"about_ca_topic_score_gemma":0.0000264697,"domain_scores_codex":[0.9990802,0.00008053688,0.0002449322,0.0002835866,0.0001627232,0.0001480486],"domain_scores_gemma":[0.9995483,0.00002501093,0.00007566355,0.0002181936,0.00008319777,0.00004961588],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0002235919,0.0007454566,0.1684003,0.0004492681,0.0003347661,0.000008109787,0.0001841438,0.0007281655,0.6724414,0.1446705,0.01147136,0.0003430283],"study_design_scores_gemma":[0.003599213,0.0003881377,0.8451582,0.00005739713,0.0001148,0.00008753745,0.0000511673,0.0000205898,0.1082996,0.02793229,0.01375214,0.0005389553],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9930946,0.0005005199,0.0005378504,0.001469918,0.0006883079,0.0001188018,0.0001769633,0.000008553147,0.003404441],"genre_scores_gemma":[0.9951583,0.00001538155,0.002338946,0.0007755682,0.0004819193,0.00000478933,0.0004666799,0.00002192768,0.0007365246],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.6767579,"threshold_uncertainty_score":0.6015761,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005705883472842208,"score_gpt":0.247342904272466,"score_spread":0.2416370207996238,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}