{"id":"W3186449140","doi":"10.1186/s13041-021-00828-0","title":"Mutation of copper binding sites on cellular prion protein abolishes its inhibitory action on NMDA receptors in mouse hippocampal neurons","year":2021,"lang":"en","type":"article","venue":"Molecular Brain","topic":"Prion Diseases and Protein Misfolding","field":"Biochemistry, Genetics and Molecular Biology","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hotchkiss Brain Institute; Alberta Children's Hospital; University of Calgary","funders":"Alberta Prion Research Institute; Alberta Innovates; Canada Research Chairs; Heart and Stroke Foundation of Canada","keywords":"Inhibitory postsynaptic potential; Hippocampal formation; Psychopharmacology; NMDA receptor; Neuroscience; Receptor; Mutation; Chemistry; Prion protein; Hippocampus; Biology; Pharmacology; Biochemistry; Medicine; Gene; Internal medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002139392,0.0001969189,0.0001677967,0.0001327276,0.00006363601,0.00003275659,0.0001136308,0.0001842783,0.00004476436],"category_scores_gemma":[0.000426895,0.0002205204,0.0001314514,0.0002109112,0.00003299017,0.00001077738,0.00006938116,0.000167463,0.00001533387],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004349179,"about_ca_system_score_gemma":0.0001063893,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000008411197,"about_ca_topic_score_gemma":0.00001375779,"domain_scores_codex":[0.9984506,0.0003203953,0.0002735636,0.0004688386,0.000244635,0.0002419964],"domain_scores_gemma":[0.9993721,0.00002340807,0.0001320651,0.0003072694,0.0000789111,0.00008620901],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001930832,0.0001606645,0.0002210735,0.0000637991,0.00002396789,0.00004161127,0.00005045582,0.0008697786,0.9906943,0.0001202763,0.0003187935,0.007242158],"study_design_scores_gemma":[0.0006563131,0.0002812501,0.0002663984,0.0001078759,0.000008117613,0.00000250515,0.00009305318,0.00008201288,0.9961571,0.0000431863,0.002088971,0.0002132542],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9975275,0.00122611,0.0002284643,0.0003242876,0.0001244068,0.0004219816,0.00002359759,0.00001748442,0.0001061041],"genre_scores_gemma":[0.9984757,0.0001388197,0.0002018949,0.0003765771,0.00008923471,0.00005491858,0.0003281434,0.00004115886,0.0002935996],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007028903,"threshold_uncertainty_score":0.8992561,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01475362097450381,"score_gpt":0.2575455342692793,"score_spread":0.2427919132947755,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}