{"id":"W3186449140","doi":"10.1186/s13041-021-00828-0","title":"Mutation of copper binding sites on cellular prion protein abolishes its inhibitory action on NMDA receptors in mouse hippocampal neurons","year":2021,"lang":"en","type":"article","venue":"Molecular Brain","topic":"Prion Diseases and Protein Misfolding","field":"Biochemistry, Genetics and Molecular Biology","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hotchkiss Brain Institute; Alberta Children's Hospital; University of Calgary","funders":"Alberta Prion Research Institute; Alberta Innovates; Canada Research Chairs; Heart and Stroke Foundation of Canada","keywords":"Inhibitory postsynaptic potential; Hippocampal formation; Psychopharmacology; NMDA receptor; Neuroscience; Receptor; Mutation; Chemistry; Prion protein; Hippocampus; Biology; Pharmacology; Biochemistry; Medicine; Gene; Internal medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001584991,0.0003674926,0.0002607512,0.0002781853,0.0001376978,0.0002103633,0.0003387004,0.0003363669,0.0009870582],"category_scores_gemma":[0.0001630993,0.0001657759,0.0002393235,0.0001361734,0.0003471558,0.0001113365,0.000147656,0.0004905197,0.0002671456],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000266248,"about_ca_system_score_gemma":0.0001702397,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001171176,"about_ca_topic_score_gemma":0.001544968,"domain_scores_codex":[0.9998028,0.00003991877,0.00003232739,0.00002855492,0.00005306757,0.00004349325],"domain_scores_gemma":[0.9997581,0.00005036398,0.00007641454,0.00003769154,0.00002038262,0.0000570789],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005494969,0.00001978485,0.00005372292,0.00001347917,0.000003644522,0.00007019599,0.000006548144,0.00002053753,0.9994967,0.00003785522,0.000007996342,0.0002145297],"study_design_scores_gemma":[0.00001814755,0.0003295686,0.002205878,0.000008249951,0.00001717757,0.0002992759,0.0000185577,0.0005358543,0.9959217,0.00003248239,0.0006095313,0.000003494025],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9979064,0.000345589,0.001092027,0.0000343981,0.00001561898,0.00001722575,0.0001158772,0.00004508098,0.0004277425],"genre_scores_gemma":[0.9971456,0.0002870312,0.001225563,0.00002461775,0.000005908801,0.00002054161,0.0001735889,0.00001977665,0.001097291],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001171176,"threshold_uncertainty_score":0.003302038,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01475362097450381,"score_gpt":0.2575455342692793,"score_spread":0.2427919132947755,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}