{"id":"W3186455232","doi":"10.1016/j.breast.2021.07.017","title":"Efficacy and safety of palbociclib in patients with estrogen receptor–positive/human epidermal growth factor receptor 2–negative advanced breast cancer with preexisting conditions: A post hoc analysis of PALOMA-2","year":2021,"lang":"en","type":"article","venue":"The Breast","topic":"Advanced Breast Cancer Therapies","field":"Medicine","cited_by":36,"is_retracted":false,"has_abstract":true,"ca_institutions":"BC Cancer Agency","funders":"Pfizer","keywords":"Palbociclib; Letrozole; Medicine; Post-hoc analysis; Internal medicine; Oncology; Adverse effect; Placebo; Breast cancer; Fulvestrant; Cancer; Common Terminology Criteria for Adverse Events; Estrogen receptor; Metastatic breast cancer; Aromatase; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003081702,0.001280994,0.002351832,0.0003967331,0.0003157143,0.0007688887,0.0007569225,0.0006053708,0.004342959],"category_scores_gemma":[0.00199708,0.0003752037,0.00288548,0.0003646897,0.0007104658,0.0007440719,0.0004499019,0.00176729,0.0005367057],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008122544,"about_ca_system_score_gemma":0.001566646,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006081197,"about_ca_topic_score_gemma":0.001649244,"domain_scores_codex":[0.9988664,0.0006338417,0.00006819333,0.0001497001,0.0001130847,0.0001686913],"domain_scores_gemma":[0.9983656,0.0005927655,0.0003791441,0.0001677835,0.0001340935,0.0003606234],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"observational","study_design_scores_codex":[0.9460148,0.007458376,0.01694778,0.0003492803,0.003168864,0.000149899,0.00007217017,0.001133701,0.008989809,0.00005591977,0.0006499163,0.01500962],"study_design_scores_gemma":[0.4174768,0.4880606,0.08026157,0.00002751114,0.004596969,0.0002868682,0.0000880826,0.002244379,0.00493337,0.0001577201,0.001822553,0.0000434389],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9978272,0.0004581177,0.0001462727,0.00008864131,0.00002753133,0.0004786912,0.0004516695,0.00001471191,0.0005070617],"genre_scores_gemma":[0.9963469,0.0002854585,0.0003822085,0.0001583733,0.0001105018,0.0006423662,0.001260233,0.00001015096,0.0008038895],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004342959,"threshold_uncertainty_score":0.01629782,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007593714205128284,"score_gpt":0.2655306533964782,"score_spread":0.25793693919135,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}