{"id":"W3186455232","doi":"10.1016/j.breast.2021.07.017","title":"Efficacy and safety of palbociclib in patients with estrogen receptor–positive/human epidermal growth factor receptor 2–negative advanced breast cancer with preexisting conditions: A post hoc analysis of PALOMA-2","year":2021,"lang":"en","type":"article","venue":"The Breast","topic":"Advanced Breast Cancer Therapies","field":"Medicine","cited_by":36,"is_retracted":false,"has_abstract":true,"ca_institutions":"BC Cancer Agency","funders":"Pfizer","keywords":"Palbociclib; Letrozole; Medicine; Post-hoc analysis; Internal medicine; Oncology; Adverse effect; Placebo; Breast cancer; Fulvestrant; Cancer; Common Terminology Criteria for Adverse Events; Estrogen receptor; Metastatic breast cancer; Aromatase; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001157926,0.0003342642,0.0009069293,0.0002157529,0.0001435247,0.00001209324,0.0001342755,0.00006895677,0.0004255055],"category_scores_gemma":[0.00005799414,0.0002232061,0.0001091837,0.00132585,0.0006301065,0.0002402963,0.00007271755,0.0002554609,0.000001042385],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001992136,"about_ca_system_score_gemma":0.0002189298,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004263951,"about_ca_topic_score_gemma":0.0003557553,"domain_scores_codex":[0.9979592,0.0002103393,0.0005404694,0.0004829828,0.0004505729,0.0003564288],"domain_scores_gemma":[0.9975009,0.0003491318,0.0005589265,0.0004051561,0.001046374,0.0001395372],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.02671264,0.000830373,0.9249026,0.000187954,0.004141452,0.00001267167,0.003871379,0.0003464386,0.01313798,0.0003304095,0.000002750094,0.02552332],"study_design_scores_gemma":[0.01066715,0.0006493432,0.9810894,0.00104442,0.0009406217,0.0000621814,0.001155966,0.00001650174,0.00410083,0.00002440787,0.000004512914,0.0002446659],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9930879,0.0003178302,0.00006936382,0.0006800983,0.00001968424,0.0007702924,0.004946968,0.00002976666,0.00007807148],"genre_scores_gemma":[0.9978982,0.00004167126,0.00119172,0.00009770059,0.0000402106,0.00006990723,0.0005771184,0.00005017005,0.00003328671],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.05618677,"threshold_uncertainty_score":0.9102079,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007593714205128284,"score_gpt":0.2655306533964782,"score_spread":0.25793693919135,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}