{"id":"W3186484195","doi":"10.3390/cancers13153733","title":"Targeting Replication Stress Using CHK1 Inhibitor Promotes Innate and NKT Cell Immune Responses and Tumour Regression","year":2021,"lang":"en","type":"article","venue":"Cancers","topic":"Immune Cell Function and Interaction","field":"Immunology and Microbiology","cited_by":21,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Sierra Oncology; Mater Foundation; Griffith University; U.S. Department of Veterans Affairs","keywords":"Innate immune system; Immune system; Replication (statistics); Immunology; Biology; Cancer research; Medicine; Virology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007007522,0.000348533,0.0002880932,0.0001713605,0.00009363708,0.0001712055,0.0001348608,0.000150225,0.00127253],"category_scores_gemma":[0.00006966214,0.00008407986,0.0001968711,0.00006640304,0.0001247081,0.0001663835,0.0001231486,0.0005587829,0.0002071573],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002031138,"about_ca_system_score_gemma":0.0001718917,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003278408,"about_ca_topic_score_gemma":0.0007884849,"domain_scores_codex":[0.9999243,0.000008236969,0.000006387231,0.00001723786,0.00001799387,0.00002580174],"domain_scores_gemma":[0.9999439,0.000008810071,0.00002021637,0.000006796621,0.000004888313,0.00001544447],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003465902,0.0001003853,0.0001967016,0.00007770492,0.000009790206,0.00003078295,0.00001223413,0.0001981056,0.9909586,0.00004767824,0.00009003447,0.007931372],"study_design_scores_gemma":[0.00007289243,0.002337032,0.003183935,0.000007610052,0.00002419455,0.0002492238,0.00001305482,0.001065801,0.9908731,0.00004077574,0.002127658,0.000004711981],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9936546,0.002992438,0.001704582,0.00009221089,0.00004300015,0.00004545378,0.0001156239,0.0001463986,0.001205745],"genre_scores_gemma":[0.9971589,0.0008432239,0.000620912,0.00002264137,0.00001311192,0.0000265353,0.0001333787,0.00000999628,0.001171491],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00127253,"threshold_uncertainty_score":0.004257023,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0156762899580847,"score_gpt":0.2621245850100974,"score_spread":0.2464482950520127,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}