{"id":"W3186484195","doi":"10.3390/cancers13153733","title":"Targeting Replication Stress Using CHK1 Inhibitor Promotes Innate and NKT Cell Immune Responses and Tumour Regression","year":2021,"lang":"en","type":"article","venue":"Cancers","topic":"Immune Cell Function and Interaction","field":"Immunology and Microbiology","cited_by":21,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Sierra Oncology; Mater Foundation; Griffith University; U.S. Department of Veterans Affairs","keywords":"Innate immune system; Immune system; Replication (statistics); Immunology; Biology; Cancer research; Medicine; Virology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001638243,0.0001154505,0.0001475178,0.00006286728,0.0002611127,0.00003028718,0.00003696125,0.0001204752,0.0001602687],"category_scores_gemma":[0.0001788408,0.0001055573,0.000025417,0.00009453666,0.00008794115,0.000150459,0.00006791749,0.0002067307,0.00001055838],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001640647,"about_ca_system_score_gemma":0.0001391708,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001532387,"about_ca_topic_score_gemma":0.000004516115,"domain_scores_codex":[0.9991169,0.0001659275,0.0002120375,0.0003222692,0.00002226052,0.0001605875],"domain_scores_gemma":[0.9994795,0.00006144172,0.0001513903,0.0001842963,0.0001071377,0.00001617427],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002189292,0.00001100738,0.000773921,0.00004202668,0.00001832285,0.000003119282,0.0004808109,0.00001607093,0.9963858,0.00001201976,0.0008394699,0.001198487],"study_design_scores_gemma":[0.0005586195,0.00005923536,0.00180848,0.0001754832,0.00001772338,0.00005723394,0.001576041,0.0002212143,0.9855041,0.000007902071,0.00988932,0.0001246374],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.979494,0.01870568,0.00007020442,0.0001753382,0.001128557,0.000115085,0.000006213956,0.00003967733,0.0002652348],"genre_scores_gemma":[0.993231,0.0008817523,0.0001109251,0.00008231747,0.00004377352,0.000009878089,0.0000962679,0.00001400152,0.005530071],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01782393,"threshold_uncertainty_score":0.4304501,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0156762899580847,"score_gpt":0.2621245850100974,"score_spread":0.2464482950520127,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}