{"id":"W3186488732","doi":"10.1016/j.gene.2021.145842","title":"Mitogen-induced transcriptional programming in human fibroblasts","year":2021,"lang":"en","type":"article","venue":"Gene","topic":"Genomics and Chromatin Dynamics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":11,"is_retracted":false,"has_abstract":false,"ca_institutions":"CancerCare Manitoba; University of Manitoba","funders":"Natural Sciences and Engineering Research Council of Canada; CancerCare Manitoba Foundation","keywords":"Biology; MAPK/ERK pathway; Mitogen-activated protein kinase; Molecular biology; Cell biology; Transcriptome; Repressor; Kinase; Gene; Epidermal growth factor; Signal transduction; Transcription factor; Phorbol; Gene expression; Cell culture; Protein kinase C; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00005735108,0.0000872629,0.00008024168,0.00002050391,0.00004633423,0.00002091618,0.0000853325,0.00009293191,0.00002792547],"category_scores_gemma":[0.000008344005,0.0001003681,0.0000626539,0.00006665922,0.0000137744,0.000001239646,0.00004380858,0.00005381415,0.000004852561],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000139243,"about_ca_system_score_gemma":0.00007075136,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000009391993,"about_ca_topic_score_gemma":0.0002297577,"domain_scores_codex":[0.9993433,0.00002268233,0.0001463367,0.0002391678,0.00006781432,0.0001806756],"domain_scores_gemma":[0.9997027,0.000001567307,0.00002558732,0.0001863177,0.00004125195,0.00004260278],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000005719091,0.00004522167,0.0007825619,0.00001010025,0.00001508833,0.000009954026,0.00004496444,0.0000949302,0.996635,0.000139878,0.00005738194,0.00215916],"study_design_scores_gemma":[0.0005795698,0.00008065,0.006907144,0.000009166769,0.000005569937,0.00003757035,0.00006859408,0.0001043469,0.982551,0.0001502964,0.009343524,0.0001625791],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9985834,0.0003725796,0.0004472261,0.00007579914,0.0001363734,0.00006809487,0.00001051608,0.000005878655,0.0003001434],"genre_scores_gemma":[0.9954062,0.00002638831,0.003342423,0.00008273765,0.0001388572,0.00001475704,0.0003601531,0.0000154094,0.0006131151],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01408405,"threshold_uncertainty_score":0.4092892,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01115514762305902,"score_gpt":0.2395768603641316,"score_spread":0.2284217127410726,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}