{"id":"W3186488732","doi":"10.1016/j.gene.2021.145842","title":"Mitogen-induced transcriptional programming in human fibroblasts","year":2021,"lang":"en","type":"article","venue":"Gene","topic":"Genomics and Chromatin Dynamics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":11,"is_retracted":false,"has_abstract":false,"ca_institutions":"CancerCare Manitoba; University of Manitoba","funders":"Natural Sciences and Engineering Research Council of Canada; CancerCare Manitoba Foundation","keywords":"Biology; MAPK/ERK pathway; Mitogen-activated protein kinase; Molecular biology; Cell biology; Transcriptome; Repressor; Kinase; Gene; Epidermal growth factor; Signal transduction; Transcription factor; Phorbol; Gene expression; Cell culture; Protein kinase C; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000114367,0.0001264303,0.0001064785,0.0002719155,0.0001651534,0.0001857059,0.0001049879,0.0001042868,0.001809145],"category_scores_gemma":[0.0001339797,0.00009473469,0.0001417498,0.0001429504,0.0001025008,0.00007206717,0.0001089309,0.0001701767,0.0003089106],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001800041,"about_ca_system_score_gemma":0.0001659092,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002492634,"about_ca_topic_score_gemma":0.00324981,"domain_scores_codex":[0.999935,0.00001649986,0.000004602494,0.00001076152,0.00001528042,0.00001782185],"domain_scores_gemma":[0.999923,0.00003235549,0.000006554174,0.00001145669,0.00000959293,0.00001708312],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002263034,0.00001378828,0.0003198562,0.00001336883,0.000001793856,0.0001088972,0.00002182394,0.00005045073,0.9977983,0.0002441284,0.00003700539,0.001164162],"study_design_scores_gemma":[0.00001813924,0.0001620231,0.01211437,0.000003544087,0.000006751387,0.0003097577,0.00006305856,0.000806744,0.9838846,0.0001539895,0.002473634,0.000003246114],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9924465,0.0009288085,0.002052319,0.00007469903,0.0000218343,0.00001739492,0.0005664728,0.00006270799,0.003829346],"genre_scores_gemma":[0.9945732,0.000305675,0.0007971181,0.00002135355,0.000005998574,0.00001607811,0.0004283126,0.00000970272,0.003842538],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002492634,"threshold_uncertainty_score":0.006052196,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01115514762305902,"score_gpt":0.2395768603641316,"score_spread":0.2284217127410726,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}