{"id":"W3186489996","doi":"10.3389/fphar.2021.713178","title":"Validation of Single Nucleotide Variant Assays for Human Leukocyte Antigen Haplotypes HLA-B*15:02 and HLA-A*31:01 Across Diverse Ancestral Backgrounds","year":2021,"lang":"en","type":"article","venue":"Frontiers in Pharmacology","topic":"Drug-Induced Adverse Reactions","field":"Medicine","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"Women and Children’s Health Research Institute; University of Alberta","funders":"Natural Sciences and Engineering Research Council of Canada; Alberta Innovates; Ministry of Innovation and Advanced Education; Canada Foundation for Innovation; University of Alberta; Alberta Innovates - Health Solutions; Faculty of Medicine and Dentistry, University of Alberta; Alberta Precision Laboratories","keywords":"Human leukocyte antigen; Haplotype; TaqMan; HLA-B; False positive paradox; Biology; Genetics; Immunology; Antigen; Allele; Gene; Polymerase chain reaction","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.008729563,0.0008078611,0.0006305697,0.001108763,0.0005599929,0.001026924,0.001010466,0.001491484,0.001334687],"category_scores_gemma":[0.01656107,0.0005668284,0.0008989392,0.001208604,0.001033666,0.000244415,0.0007160662,0.0009054741,0.000888038],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004337053,"about_ca_system_score_gemma":0.000560711,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002518879,"about_ca_topic_score_gemma":0.004328807,"domain_scores_codex":[0.984805,0.005503909,0.001041149,0.0043934,0.00367639,0.0005800104],"domain_scores_gemma":[0.9911427,0.00418178,0.001185914,0.001482643,0.001738605,0.0002682381],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002421272,0.0009336502,0.24037,0.0004883644,0.001600985,0.0005311161,0.002651494,0.006794403,0.7029074,0.001510169,0.00149693,0.03829417],"study_design_scores_gemma":[0.0004202585,0.005225693,0.4321153,0.0001759723,0.001350699,0.003186015,0.0006203276,0.02461076,0.5144971,0.001655938,0.01596223,0.0001796876],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.934265,0.0009060081,0.05779039,0.0001927316,0.0001795382,0.0005821143,0.002943082,0.000266795,0.00287436],"genre_scores_gemma":[0.9417041,0.0003887933,0.04947971,0.0005051706,0.00005528774,0.001031485,0.004084078,0.0001243829,0.002626964],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.008729563,"threshold_uncertainty_score":0.0461669,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05005680927064726,"score_gpt":0.3529138120858749,"score_spread":0.3028570028152276,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}