{"id":"W3186495549","doi":"10.1039/d1sc00749a","title":"Mechanistic insights into dopaminergic and serotonergic neurotransmission – concerted interactions with helices 5 and 6 drive the functional outcome","year":2021,"lang":"en","type":"article","venue":"Chemical Science","topic":"Receptor Mechanisms and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":19,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Institute for Research in Immunology and Cancer","funders":"Instituto de Salud Carlos III; Ministerio de Asuntos Económicos y Transformación Digital, Gobierno de España; Ministerio de Ciencia e Innovación; Ministerio de Ciencia, Innovación y Universidades","keywords":"Serotonergic; Dopaminergic; Neuroscience; Neurotransmitter; Neurotransmission; Transmembrane domain; Neurotransmitter receptor; Helix (gastropod); Chemistry; Receptor; Biology; Dopamine; Serotonin; Biochemistry; Central nervous system; Ecology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001589684,0.0001906235,0.0001126165,0.00007370807,0.0002081207,0.0003382796,0.0001939487,0.0003324917,0.003179691],"category_scores_gemma":[0.0001016441,0.00008783465,0.0001864379,0.00004478601,0.0002415331,0.0003392349,0.0001515921,0.0005150641,0.0006247453],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002659456,"about_ca_system_score_gemma":0.0001865771,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003702629,"about_ca_topic_score_gemma":0.0007031219,"domain_scores_codex":[0.9999447,0.000008120328,0.00000321615,0.00001351645,0.00001383145,0.00001666067],"domain_scores_gemma":[0.9999628,0.000005358775,0.00001112937,0.000004331655,0.000004004487,0.00001241682],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001704246,0.00003062257,0.0007242038,0.00006047828,0.000009687004,0.0002685352,0.00003724371,0.0008866849,0.9878173,0.005900039,0.0002972859,0.003797452],"study_design_scores_gemma":[0.00005992965,0.0003959815,0.01393634,0.00003607986,0.0000507976,0.001323404,0.0002489486,0.0189992,0.9409505,0.004767395,0.01919529,0.00003619835],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9775834,0.001590538,0.009652276,0.0009998339,0.0001192945,0.00002054765,0.0002487584,0.0001358797,0.009649509],"genre_scores_gemma":[0.995464,0.0004842566,0.002138559,0.0001145537,0.000008649527,0.000004375072,0.00007272107,0.000007706214,0.00170518],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003179691,"threshold_uncertainty_score":0.01063716,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01320167763516437,"score_gpt":0.2520683219907322,"score_spread":0.2388666443555678,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}