{"id":"W3186495549","doi":"10.1039/d1sc00749a","title":"Mechanistic insights into dopaminergic and serotonergic neurotransmission – concerted interactions with helices 5 and 6 drive the functional outcome","year":2021,"lang":"en","type":"article","venue":"Chemical Science","topic":"Receptor Mechanisms and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":19,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Institute for Research in Immunology and Cancer","funders":"Instituto de Salud Carlos III; Ministerio de Asuntos Económicos y Transformación Digital, Gobierno de España; Ministerio de Ciencia e Innovación; Ministerio de Ciencia, Innovación y Universidades","keywords":"Serotonergic; Dopaminergic; Neuroscience; Neurotransmitter; Neurotransmission; Transmembrane domain; Neurotransmitter receptor; Helix (gastropod); Chemistry; Receptor; Biology; Dopamine; Serotonin; Biochemistry; Central nervous system; Ecology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007371949,0.00009365655,0.00007781135,0.00001586593,0.0002520615,0.00006945514,0.0001008905,0.00003620493,0.00004297041],"category_scores_gemma":[0.0000525133,0.00005561951,0.00001803246,0.0001521009,0.0003204922,0.00001231717,0.0001093493,0.00008859736,0.000001038298],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000008719383,"about_ca_system_score_gemma":0.00006396163,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001165452,"about_ca_topic_score_gemma":0.00001127818,"domain_scores_codex":[0.9992324,0.0000183942,0.0001015908,0.0003622402,0.0001568212,0.0001285249],"domain_scores_gemma":[0.9996009,0.00002612034,0.00003459021,0.0001277598,0.0001018473,0.0001087549],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001875438,0.00001118233,0.0002019273,0.00000694294,0.000004726819,0.000002929742,0.00006224207,0.00001336773,0.9986101,0.0005314559,0.00000850471,0.0005278168],"study_design_scores_gemma":[0.0001975606,0.00006006584,0.0005019292,0.00001414794,0.00001139747,0.00007290701,0.0001676972,0.001174663,0.9954145,0.0004297444,0.001858287,0.00009708583],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9936598,0.0003585899,0.00534713,0.0003055628,0.00008211724,0.00007186093,7.766724e-7,0.000007098667,0.0001670716],"genre_scores_gemma":[0.9988078,0.00007059019,0.0006503696,0.0002562041,0.00005057181,0.00001461788,0.00000996531,0.000005309195,0.0001345997],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00514798,"threshold_uncertainty_score":0.2268098,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01320167763516437,"score_gpt":0.2520683219907322,"score_spread":0.2388666443555678,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}