{"id":"W3186547303","doi":"10.1042/bsr20210952","title":"Targeting the ‘garbage-bin’ to fight cancer: HDAC6 inhibitor WT161 has an anti-tumor effect on osteosarcoma and synergistically interacts with 5-FU","year":2021,"lang":"en","type":"article","venue":"Bioscience Reports","topic":"Peptidase Inhibition and Analysis","field":"Medicine","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"Children's Hospital of Eastern Ontario; University of Ottawa","funders":"","keywords":"HDAC6; Aggresome; Acetylation; Endoplasmic reticulum; Unfolded protein response; Protein folding; Chemistry; Cell biology; Protein disulfide-isomerase; Cell; Osteosarcoma; Cancer research; Biology; Histone; Histone deacetylase; Biochemistry; Apoptosis; Autophagy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001041494,0.0002850917,0.0003427867,0.0002374686,0.0001078095,0.0001938772,0.0001831129,0.0001756851,0.001935388],"category_scores_gemma":[0.00003931228,0.0001347692,0.0002785266,0.0002017034,0.0001595067,0.0001898405,0.0001321315,0.0004960752,0.0003834773],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001684207,"about_ca_system_score_gemma":0.0001722733,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005917535,"about_ca_topic_score_gemma":0.001833133,"domain_scores_codex":[0.9999554,0.000004756051,0.000004227401,0.000008778035,0.00001343822,0.00001336715],"domain_scores_gemma":[0.9999804,0.000001566439,0.000005311014,0.000002338758,0.000002499432,0.000007758997],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0008321442,0.0002187724,0.0003256502,0.000151122,0.00003632872,0.00008672613,0.00002016388,0.0002766938,0.9755906,0.0002391383,0.0007831344,0.02143959],"study_design_scores_gemma":[0.0001712542,0.002144812,0.003399562,0.000009927146,0.00006822708,0.0004270835,0.00001559634,0.0007871783,0.9766874,0.00006588735,0.01621432,0.000008822215],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9740095,0.01676877,0.002341016,0.0007323384,0.0001989599,0.00006712141,0.0005041577,0.0003429199,0.005035178],"genre_scores_gemma":[0.9813607,0.008741309,0.002665692,0.0001857254,0.00003615846,0.00003469958,0.0006752979,0.00002802409,0.006272402],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001935388,"threshold_uncertainty_score":0.006474555,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01361734211477738,"score_gpt":0.2812234557012027,"score_spread":0.2676061135864253,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}