{"id":"W3186547303","doi":"10.1042/bsr20210952","title":"Targeting the ‘garbage-bin’ to fight cancer: HDAC6 inhibitor WT161 has an anti-tumor effect on osteosarcoma and synergistically interacts with 5-FU","year":2021,"lang":"en","type":"article","venue":"Bioscience Reports","topic":"Peptidase Inhibition and Analysis","field":"Medicine","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"Children's Hospital of Eastern Ontario; University of Ottawa","funders":"","keywords":"HDAC6; Aggresome; Acetylation; Endoplasmic reticulum; Unfolded protein response; Protein folding; Chemistry; Cell biology; Protein disulfide-isomerase; Cell; Osteosarcoma; Cancer research; Biology; Histone; Histone deacetylase; Biochemistry; Apoptosis; Autophagy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006217775,0.0002103779,0.0003450387,0.0001190407,0.0003672524,0.0002256387,0.00007806624,0.00004326113,0.0001309592],"category_scores_gemma":[0.001100093,0.0001202643,0.00007185443,0.000681655,0.0002698383,0.0001511771,0.00008501649,0.0002010214,0.000009758931],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000077,"about_ca_system_score_gemma":0.0003583375,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000117863,"about_ca_topic_score_gemma":0.00009387827,"domain_scores_codex":[0.9978301,0.0001070337,0.000371313,0.0007153251,0.0006117893,0.0003644471],"domain_scores_gemma":[0.9985779,0.0001289609,0.0001782933,0.0004845256,0.0002089462,0.0004213613],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001135657,0.0002663959,0.01846794,0.0001071812,0.0000371604,0.01933077,0.00031374,0.00004535325,0.9538971,0.00006220588,0.002337794,0.005020821],"study_design_scores_gemma":[0.0007975484,0.002240739,0.06064916,0.003231667,0.0002223058,0.005898452,0.0003651992,0.00179762,0.9097759,0.00001532526,0.01445374,0.000552374],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.993227,0.0001282601,0.0001687808,0.00527553,0.0001352413,0.000292993,0.000008133899,0.00006325062,0.0007008152],"genre_scores_gemma":[0.9952512,0.00001133104,0.0004503691,0.00355887,0.000212287,0.00003655406,0.00001906038,0.00001679053,0.000443563],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04412121,"threshold_uncertainty_score":0.4904237,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01361734211477738,"score_gpt":0.2812234557012027,"score_spread":0.2676061135864253,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}