{"id":"W3186549587","doi":"10.1177/00368504211024113","title":"An optimal non-viral gene transfer method for genetically modifying porcine bone marrow-derived endothelial progenitor cells for experimental therapeutics","year":2021,"lang":"en","type":"article","venue":"Science Progress","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; St. Michael's Hospital","funders":"Heart and Stroke Foundation of Canada","keywords":"Bone marrow; Gene transfer; Progenitor cell; Genetically modified organism; Genetic enhancement; Biology; Stem cell; Gene; Cell biology; Virology; Immunology; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000575055,0.0005876194,0.0004067132,0.0006394321,0.0002827863,0.0004626743,0.0003426727,0.0007061105,0.001163384],"category_scores_gemma":[0.0003619218,0.000274383,0.0004547278,0.0003447667,0.0003384391,0.0003758753,0.0002610989,0.0007873677,0.0007406478],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002124672,"about_ca_system_score_gemma":0.0003677273,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002262906,"about_ca_topic_score_gemma":0.0004631361,"domain_scores_codex":[0.9994857,0.00009612655,0.00005921016,0.0001100322,0.0001815891,0.0000673269],"domain_scores_gemma":[0.9998678,0.00003034414,0.00004456078,0.00001995266,0.00002101961,0.00001629607],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003002428,0.00003716966,0.00006452448,0.00009969891,0.000004010512,0.00004836063,0.00001729394,0.0001191993,0.996191,0.0002580898,0.00006907912,0.003061475],"study_design_scores_gemma":[0.00003856287,0.0006638986,0.001485046,0.00003815102,0.0000512393,0.0005616577,0.00001991976,0.001695903,0.9829568,0.0001996703,0.01226634,0.00002292134],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.6075478,0.01825938,0.3576747,0.0006875944,0.0007061971,0.001834225,0.00104033,0.0007165581,0.01153317],"genre_scores_gemma":[0.7713929,0.008757112,0.211053,0.0002910312,0.0001501587,0.001719204,0.001113237,0.000168688,0.005354782],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001163384,"threshold_uncertainty_score":0.003891945,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03190515164453639,"score_gpt":0.3740827643721178,"score_spread":0.3421776127275815,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}