{"id":"W3186613594","doi":"10.1111/tri.13997","title":"Pharmacokinetics of a once‐daily tacrolimus formulation in first nations and caucasian liver transplant recipients","year":2021,"lang":"en","type":"article","venue":"Transplant International","topic":"Renal Transplantation Outcomes and Treatments","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University; University of Manitoba","funders":"","keywords":"Tacrolimus; Cmin; Medicine; Cmax; Pharmacokinetics; CYP3A5; CYP3A4; Liver transplantation; Population; Gastroenterology; Internal medicine; Pharmacology; Urology; Genotype; Transplantation; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002672901,0.000124078,0.0001911856,0.0001862965,0.0003176338,0.0003022945,0.00009042609,0.000131778,0.000671833],"category_scores_gemma":[0.0006455317,0.00007730709,0.0001453108,0.0001796423,0.0001911018,0.0001222526,0.0001007216,0.0001712328,0.00008318824],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008740142,"about_ca_system_score_gemma":0.0005654786,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.06460281,"about_ca_topic_score_gemma":0.07828047,"domain_scores_codex":[0.9998552,0.00002557846,0.000009324781,0.0000234879,0.00004575705,0.0000406517],"domain_scores_gemma":[0.9996918,0.00004479493,0.00008043288,0.00001656567,0.00003468284,0.0001317518],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.005597287,0.0003124697,0.9387323,0.00003012008,0.00008202727,0.0005455061,0.0009113814,0.0002042629,0.03756341,0.0001061194,0.0002482701,0.01566684],"study_design_scores_gemma":[0.00002040532,0.0008171204,0.997319,0.000002131598,0.00002053954,0.0004636502,0.000241709,0.000220114,0.0006789168,0.00001093269,0.000200353,0.000005134842],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9997945,0.00003419182,0.00001383287,0.000005685945,8.46388e-7,0.000001639035,0.00001302081,7.472804e-7,0.0001355308],"genre_scores_gemma":[0.9998034,0.00002304588,0.00003294361,0.00001181415,0.00000153014,0.000001480721,0.00003435414,7.143832e-7,0.00009075183],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.06460281,"threshold_uncertainty_score":0.1284536,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02546043425590013,"score_gpt":0.3042170370098066,"score_spread":0.2787566027539065,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}