{"id":"W3186613594","doi":"10.1111/tri.13997","title":"Pharmacokinetics of a once‐daily tacrolimus formulation in first nations and caucasian liver transplant recipients","year":2021,"lang":"en","type":"article","venue":"Transplant International","topic":"Renal Transplantation Outcomes and Treatments","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University; University of Manitoba","funders":"","keywords":"Tacrolimus; Cmin; Medicine; Cmax; Pharmacokinetics; CYP3A5; CYP3A4; Liver transplantation; Population; Gastroenterology; Internal medicine; Pharmacology; Urology; Genotype; Transplantation; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00006187776,0.0001380956,0.0002157055,0.0002482746,0.00005075049,0.0000135585,0.00006042559,0.00006687636,0.0002791359],"category_scores_gemma":[0.00001031989,0.0001279605,0.00008557854,0.0001925902,0.00002912025,0.0001228793,0.000005082281,0.0001124333,0.000007211861],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005923944,"about_ca_system_score_gemma":0.00006051433,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001129571,"about_ca_topic_score_gemma":0.001169056,"domain_scores_codex":[0.9988866,0.00002193431,0.0003860065,0.0002217386,0.000336123,0.0001475446],"domain_scores_gemma":[0.9994977,0.0001425303,0.00006843439,0.0000876091,0.0001208292,0.00008290624],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001016445,0.0007795754,0.980952,0.0004876923,0.0004220909,0.001381492,0.004101766,0.0003046555,0.004582352,0.003762352,0.00001115019,0.002198379],"study_design_scores_gemma":[0.009271274,0.0001262774,0.965793,0.00176624,0.0002999965,0.001110528,0.00005138906,0.0070267,0.01332467,0.0000714762,0.0009762025,0.0001822139],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9903522,0.0002350995,0.00123368,0.0009012606,0.0002780048,0.0002710863,0.0007346534,0.00002145504,0.005972556],"genre_scores_gemma":[0.9927563,0.00452596,0.001185473,0.00009548539,0.00003925175,0.00001810289,0.0009465651,0.00001321607,0.0004196228],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01515902,"threshold_uncertainty_score":0.5218077,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02546043425590013,"score_gpt":0.3042170370098066,"score_spread":0.2787566027539065,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}