{"id":"W3186655313","doi":"10.3390/genes14040854","title":"Retinal Phenotyping of a Murine Model of Lafora Disease","year":2023,"lang":"en","type":"article","venue":"Genes","topic":"Glycogen Storage Diseases and Myoclonus","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Toronto Centre for Phenogenomics; Hospital for Sick Children; University of Toronto","funders":"","keywords":"Retinal; Outer nuclear layer; Ex vivo; In vivo; Pathology; Erg; Retinal degeneration; Electroretinography; Retina; Phenotype; Biology; Chemistry; Ophthalmology; Medicine; Neuroscience; Biochemistry; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004228534,0.0009195974,0.0003656609,0.001728198,0.0003596893,0.000347601,0.0003456861,0.0008427744,0.001765239],"category_scores_gemma":[0.0002136515,0.0003306848,0.000451531,0.0002916791,0.0003726398,0.0004493889,0.0003911311,0.001106942,0.0005864406],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004860374,"about_ca_system_score_gemma":0.0001832296,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006964772,"about_ca_topic_score_gemma":0.001261266,"domain_scores_codex":[0.9995254,0.00006345097,0.00005816517,0.0001626833,0.0001193287,0.00007107039],"domain_scores_gemma":[0.9996019,0.00003277823,0.0001439135,0.00005071318,0.0000501094,0.000120544],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0001861684,0.0001517402,0.0008684738,0.00004204307,0.00001425466,0.0003709586,0.00003682391,0.00009424824,0.9966398,0.0001386686,0.00009462669,0.001362208],"study_design_scores_gemma":[0.0001419533,0.004179677,0.04687011,0.00008855612,0.0001710007,0.007902339,0.0001895595,0.003280828,0.9294669,0.0003298729,0.007332255,0.00004697451],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9825864,0.002010799,0.00939892,0.0001935359,0.00005512829,0.0002432785,0.001825989,0.0003769822,0.003308967],"genre_scores_gemma":[0.9721182,0.001962989,0.01475793,0.0002193356,0.00002622281,0.000460396,0.002601023,0.0001186446,0.007735366],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001765239,"threshold_uncertainty_score":0.00590533,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03746515392690439,"score_gpt":0.2863415925922587,"score_spread":0.2488764386653543,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}