{"id":"W3186671772","doi":"10.1038/s41589-021-00750-5","title":"Reply to: Binding site for MDL-801 on SIRT6","year":2021,"lang":"en","type":"letter","venue":"Nature Chemical Biology","topic":"Sirtuins and Resveratrol in Medicine","field":"Medicine","cited_by":11,"is_retracted":false,"has_abstract":false,"ca_institutions":"Structural Genomics Consortium; University of Toronto","funders":"","keywords":"Computational biology; Binding site; Chemistry; Biology; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","research_integrity"],"consensus_categories":["research_integrity"],"category_scores_codex":[0.0002142127,0.0004802024,0.00117793,0.0002448632,0.00005738315,0.00001428417,0.0002517947,0.005412229,0.0003201483],"category_scores_gemma":[0.002153854,0.0003264402,0.0004208657,0.0002919224,0.0001361489,0.000009020177,0.0001104628,0.006663725,0.0001108555],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001898279,"about_ca_system_score_gemma":0.0001366246,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000006242664,"about_ca_topic_score_gemma":4.521858e-7,"domain_scores_codex":[0.9974012,0.00005335442,0.0004412642,0.001098883,0.0002852989,0.0007199804],"domain_scores_gemma":[0.9978044,0.0008507527,0.0001385574,0.0007256446,0.0002646764,0.0002159948],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0002543654,0.00003705435,0.00005303655,0.0002124546,0.0001576862,0.0004120922,0.00001496712,4.344268e-8,0.229686,0.00002279779,0.7672183,0.001931244],"study_design_scores_gemma":[0.001442872,0.0007410797,0.000009554801,0.0005266328,0.000213864,0.0001854762,0.000006457697,0.000004739402,0.05426729,0.0000597441,0.9422253,0.0003169588],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"commentary","genre_gemma":"commentary","genre_scores_codex":[0.02377845,0.00304245,0.00002970708,0.9663607,0.003112547,0.0008996135,0.0003674721,0.00011057,0.002298502],"genre_scores_gemma":[0.002781107,0.0001282793,0.001577257,0.9532328,0.0250813,0.0001034567,0.0113794,0.00008834612,0.005628068],"genre_candidate":"commentary","genre_consensus":"commentary","teacher_disagreement_score":0.1754187,"threshold_uncertainty_score":0.9999188,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01596420179355239,"score_gpt":0.316521312846669,"score_spread":0.3005571110531166,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}