{"id":"W3186671772","doi":"10.1038/s41589-021-00750-5","title":"Reply to: Binding site for MDL-801 on SIRT6","year":2021,"lang":"en","type":"letter","venue":"Nature Chemical Biology","topic":"Sirtuins and Resveratrol in Medicine","field":"Medicine","cited_by":11,"is_retracted":false,"has_abstract":false,"ca_institutions":"Structural Genomics Consortium; University of Toronto","funders":"","keywords":"Computational biology; Binding site; Chemistry; Biology; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003072799,0.001166333,0.002029206,0.0007188096,0.004687479,0.003426758,0.001946467,0.06733071,0.009641353],"category_scores_gemma":[0.02089655,0.0010806,0.001719444,0.0005761286,0.00308903,0.002900603,0.002528266,0.05125046,0.009478413],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.005082679,"about_ca_system_score_gemma":0.003969145,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004185168,"about_ca_topic_score_gemma":0.005373032,"domain_scores_codex":[0.9979426,0.0004594043,0.0002372842,0.0003148584,0.000629305,0.0004164098],"domain_scores_gemma":[0.9944342,0.002995788,0.0004502012,0.0002025614,0.0008900759,0.001027267],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00009247593,0.00002276611,0.0002542966,0.00005166998,0.00002076093,0.001055848,0.00008163448,0.00004391846,0.0002550436,0.0009795203,0.9939935,0.003148592],"study_design_scores_gemma":[0.000388561,0.0001618955,0.001486962,0.0003225806,0.00011181,0.00204453,0.0005815512,0.0005604694,0.0007445292,0.008894509,0.9845823,0.0001202048],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"commentary","genre_gemma":"commentary","genre_scores_codex":[0.0002689797,0.001028417,0.00007857837,0.9615421,0.03614096,0.00001110991,0.00008111014,0.00002700843,0.0008216911],"genre_scores_gemma":[0.002239394,0.0008252107,0.000116442,0.9538308,0.03804233,0.0000476545,0.00004810866,0.0000199779,0.004829981],"genre_candidate":"commentary","genre_consensus":"commentary","teacher_disagreement_score":0.06733071,"threshold_uncertainty_score":0.03687763,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01596420179355239,"score_gpt":0.316521312846669,"score_spread":0.3005571110531166,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}