{"id":"W3186720853","doi":"10.1016/j.celrep.2021.109443","title":"SMAD4 represses FOSL1 expression and pancreatic cancer metastatic colonization","year":2021,"lang":"en","type":"article","venue":"Cell Reports","topic":"Pancreatic and Hepatic Oncology Research","field":"Medicine","cited_by":47,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre","funders":"National Cancer Institute; Dana-Farber Cancer Institute; American Cancer Society; American Association for Cancer Research; Merck; U.S. Department of Defense","keywords":"Colonization; Metastasis; Pancreatic cancer; Effector; Biology; Cancer research; Cancer; Transforming growth factor; Gene; In vivo; Medicine; Immunology; Genetics; Cell biology; Microbiology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002688669,0.0001160148,0.0004334341,0.00005493155,0.000103834,0.00002319072,0.00002293321,0.00007458035,0.0008644402],"category_scores_gemma":[0.000671017,0.00009467052,0.00004246731,0.0001795851,0.00008841305,0.00006149623,0.00006995154,0.000134654,0.00000745786],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005814,"about_ca_system_score_gemma":0.0005643418,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00009349049,"about_ca_topic_score_gemma":0.00001770738,"domain_scores_codex":[0.9986787,0.00009402599,0.0003472203,0.0003799341,0.0002764441,0.0002236307],"domain_scores_gemma":[0.9988252,0.0001862323,0.0001536523,0.0004000915,0.0002526756,0.0001821823],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000803275,0.0002620577,0.8518152,0.0006416404,0.00009947601,0.008277853,0.0004227466,0.000008856834,0.1303033,0.00002081682,0.006734712,0.001333061],"study_design_scores_gemma":[0.002820293,0.0004324695,0.3737378,0.00112187,0.001989279,0.006414762,0.0009001254,0.00113475,0.5862665,0.001826895,0.02290574,0.0004495731],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9748129,0.007403203,0.0005525788,0.0004222839,0.0001397608,0.0003586605,0.000002487868,0.00004184231,0.01626626],"genre_scores_gemma":[0.9760863,0.001896095,0.003646869,0.0002158982,0.00007608952,0.0001044908,0.00006239965,0.00002052283,0.01789134],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4780774,"threshold_uncertainty_score":0.9465014,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03701883849348835,"score_gpt":0.347302403194267,"score_spread":0.3102835647007786,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}