{"id":"W3186731930","doi":"10.1371/journal.pcbi.1008577","title":"Immune selection suppresses the emergence of drug resistance in malaria parasites but facilitates its spread","year":2021,"lang":"en","type":"article","venue":"PLoS Computational Biology","topic":"Malaria Research and Control","field":"Medicine","cited_by":27,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"Natural Sciences and Engineering Research Council of Canada; National Institutes of Health","keywords":"Biology; Immune system; Transmission (telecommunications); Population; Immunity; Drug resistance; Selective sweep; Selection (genetic algorithm); Acquired immune system; Malaria; Virology; Evolutionary biology; Immunology; Genetics; Gene; Genotype; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001879816,0.00008404995,0.0002274907,0.00006937687,0.00005293481,0.000006806055,0.00009488531,0.00005060537,0.0005858917],"category_scores_gemma":[0.0008726493,0.00006166174,0.00005277121,0.0002801955,0.00009413471,0.00003946143,0.00003967049,0.0001691012,0.00002333228],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001557356,"about_ca_system_score_gemma":0.0002154219,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005602638,"about_ca_topic_score_gemma":0.0001432775,"domain_scores_codex":[0.9988916,0.0002555858,0.0002896271,0.0002081809,0.0001629531,0.0001920556],"domain_scores_gemma":[0.9985312,0.0008038121,0.00006495466,0.0001078137,0.0004536992,0.0000384958],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.001272619,0.0005868895,0.1289795,0.0003368847,0.0003772787,0.00004398486,0.0006062223,0.001800295,0.7750303,0.08942991,0.001045067,0.0004910821],"study_design_scores_gemma":[0.001856061,0.0001711883,0.8251451,0.0001240106,0.0000502683,0.00002885531,0.000346906,0.01502686,0.1334231,0.02299945,0.0006739391,0.0001542483],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9705592,0.00634921,0.001154987,0.02059136,0.00007069842,0.0003760118,0.00008025713,0.00002313507,0.0007951682],"genre_scores_gemma":[0.997191,0.0001067006,0.00141458,0.0001030966,0.00003795099,0.0000472276,0.0001716348,0.000004954174,0.000922884],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.6961656,"threshold_uncertainty_score":0.6415102,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02067922761460399,"score_gpt":0.2904148895948755,"score_spread":0.2697356619802715,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}