{"id":"W3186779699","doi":"10.1021/acs.analchem.1c02227","title":"CRISPR Technique Incorporated with Single-Cell RNA Sequencing for Studying Hepatitis B Infection","year":2021,"lang":"en","type":"article","venue":"Analytical Chemistry","topic":"Hepatitis B Virus Studies","field":"Medicine","cited_by":16,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; Alberta Innovates","keywords":"Chemistry; CRISPR; RNA; Computational biology; Virology; Molecular biology; Gene; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001421007,0.0001906985,0.0003834341,0.00003149438,0.0001247508,0.00002453683,0.00004032828,0.0001439791,0.0001158297],"category_scores_gemma":[0.0004492947,0.0001721001,0.00009828052,0.0004051283,0.00009467337,0.00006368708,0.00005703284,0.0002628294,0.000008321397],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004172881,"about_ca_system_score_gemma":0.0003210895,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004480092,"about_ca_topic_score_gemma":0.0002346519,"domain_scores_codex":[0.9987685,0.00001785511,0.0003030226,0.0003779967,0.0002427099,0.0002899317],"domain_scores_gemma":[0.9988118,0.0001147297,0.00009321869,0.0002725199,0.0005596516,0.0001481002],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006612311,0.0002790402,0.3171146,0.0008120893,0.0001916631,0.0004152421,0.00006190506,0.00001473951,0.6796868,0.00002250622,0.0009840188,0.0003512763],"study_design_scores_gemma":[0.0008200928,0.0002197005,0.003382664,0.0003030981,0.0003501187,0.0001421609,0.0000617074,0.00126973,0.9922072,0.0001142606,0.0008977451,0.0002314852],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9496114,0.0001084311,0.02836434,0.0003742514,0.00002848587,0.000394427,0.00001574683,0.0001797118,0.0209232],"genre_scores_gemma":[0.991382,0.00005529926,0.006431058,0.0002571098,0.0001572859,0.0001206217,0.00007140162,0.0000374384,0.001487761],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3137319,"threshold_uncertainty_score":0.7018039,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04515776452452821,"score_gpt":0.285592530659319,"score_spread":0.2404347661347908,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}