{"id":"W3186779699","doi":"10.1021/acs.analchem.1c02227","title":"CRISPR Technique Incorporated with Single-Cell RNA Sequencing for Studying Hepatitis B Infection","year":2021,"lang":"en","type":"article","venue":"Analytical Chemistry","topic":"Hepatitis B Virus Studies","field":"Medicine","cited_by":16,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; Alberta Innovates","keywords":"Chemistry; CRISPR; RNA; Computational biology; Virology; Molecular biology; Gene; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005593931,0.0003686687,0.0005091305,0.0004119357,0.0004137768,0.0004678272,0.0003663448,0.0006216078,0.001622389],"category_scores_gemma":[0.0003656268,0.0003340479,0.000373114,0.0002615028,0.0003374924,0.0002716307,0.0004445893,0.00086132,0.0009398866],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002991999,"about_ca_system_score_gemma":0.0003511032,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006147145,"about_ca_topic_score_gemma":0.001423358,"domain_scores_codex":[0.9995727,0.00008185831,0.00002841032,0.0001401346,0.0001385273,0.00003831221],"domain_scores_gemma":[0.9996804,0.0001085857,0.00005112522,0.0000770566,0.00004681525,0.00003599676],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001897216,0.000009129849,0.0001146645,0.00003889872,0.000006262275,0.00002459937,0.00001959109,0.000142944,0.9966902,0.0001897421,0.00009093557,0.002654077],"study_design_scores_gemma":[0.000007042578,0.0001220349,0.001755528,0.000007382684,0.00001666244,0.0002460738,0.00001996654,0.004325561,0.987329,0.0002601845,0.005893665,0.00001682056],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"methods","genre_gemma":"methods","genre_scores_codex":[0.3265045,0.001907237,0.6575599,0.0002951273,0.0002508741,0.0004468552,0.002828078,0.003775807,0.006431669],"genre_scores_gemma":[0.4684339,0.002075565,0.5163298,0.0004177222,0.00005336585,0.0009413992,0.00269935,0.0006428951,0.008405969],"genre_candidate":"methods","genre_consensus":"methods","teacher_disagreement_score":0.001622389,"threshold_uncertainty_score":0.00542742,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04515776452452821,"score_gpt":0.285592530659319,"score_spread":0.2404347661347908,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}