{"id":"W3186790358","doi":"10.1083/jcb.202009028","title":"Intracellular nanovesicles mediate α5β1 integrin trafficking during cell migration","year":2021,"lang":"en","type":"article","venue":"The Journal of Cell Biology","topic":"Cellular transport and secretion","field":"Biochemistry, Genetics and Molecular Biology","cited_by":18,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"University of Warwick; Medical Research Council; Biotechnology and Biological Sciences Research Council; Fonds de Recherche du Québec - Santé; Fonds de recherche du Québec; University of Oxford","keywords":"Endocytosis; Rab; Cell biology; Biology; Integrin; Cell migration; Intracellular; GTPase-activating protein; Cell; Cell membrane; GTPase; Cell adhesion; Membrane protein; Motility; Signal transduction; G protein; Biochemistry; Membrane","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007967932,0.0002253884,0.0001629521,0.00016365,0.0001945451,0.0004226652,0.0001221908,0.0003000554,0.000948954],"category_scores_gemma":[0.0000902192,0.0001037869,0.0002548902,0.00007648516,0.0001388272,0.0002951833,0.0002956342,0.0002880091,0.0005368136],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003708494,"about_ca_system_score_gemma":0.000137379,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006108176,"about_ca_topic_score_gemma":0.0008181452,"domain_scores_codex":[0.9998922,0.00001592334,0.00000782428,0.00001936491,0.00002589893,0.00003876227],"domain_scores_gemma":[0.999945,0.000006758301,0.00001327553,0.000007096735,0.0000122481,0.00001556328],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003654411,0.000004873817,0.0002143066,0.00001952079,0.000001761453,0.00005472449,0.00001316974,0.00002321277,0.9986229,0.0001709775,0.00003290716,0.0008050699],"study_design_scores_gemma":[0.000008569638,0.00007115013,0.009508929,0.00001467332,0.000008743744,0.0002916095,0.00009135639,0.0009921042,0.9843396,0.00009987807,0.004568617,0.000004726694],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9912162,0.002914314,0.002784275,0.0001168173,0.00003177181,0.00001606352,0.0001241997,0.00005151884,0.002744887],"genre_scores_gemma":[0.9942045,0.0009251183,0.001514929,0.00005244187,0.000007419349,0.00001978423,0.0001874655,0.00001353181,0.003074836],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.000948954,"threshold_uncertainty_score":0.003174603,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006320797740111755,"score_gpt":0.2031792478896855,"score_spread":0.1968584501495737,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}