{"id":"W3186824561","doi":"10.3390/mps4030050","title":"A Multistep Workflow to Evaluate Newly Generated iPSCs and Their Ability to Generate Different Cell Types","year":2021,"lang":"en","type":"article","venue":"Methods and Protocols","topic":"Pluripotent Stem Cells Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":84,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Montreal Neurological Institute and Hospital","funders":"Canadian Institutes of Health Research","keywords":"Induced pluripotent stem cell; Workflow; Somatic cell; Computer science; Computational biology; Biology; Embryonic stem cell; Genetics; Database; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.007815781,0.001953218,0.001252268,0.002868735,0.001476697,0.002432432,0.001942706,0.001323651,0.004401254],"category_scores_gemma":[0.006270809,0.001110625,0.001526529,0.001072426,0.001139804,0.0009204114,0.002214707,0.002316111,0.004250958],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001177816,"about_ca_system_score_gemma":0.002999019,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002229755,"about_ca_topic_score_gemma":0.003051352,"domain_scores_codex":[0.9917111,0.0009221385,0.001370605,0.00173066,0.003753389,0.0005120041],"domain_scores_gemma":[0.9924212,0.001492149,0.0007486556,0.001831533,0.003050569,0.0004559948],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003468031,0.0001801168,0.00238557,0.0003203606,0.00006053548,0.0002791824,0.0003726953,0.001533273,0.9655515,0.001203591,0.001833402,0.02593292],"study_design_scores_gemma":[0.0000360811,0.0003917827,0.003733716,0.0000966144,0.0000790987,0.0003378093,0.00008522117,0.005389973,0.9707658,0.0008397171,0.01810308,0.0001410322],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"methods","genre_gemma":"methods","genre_scores_codex":[0.08585336,0.0010447,0.8765072,0.0005198481,0.0004938538,0.006996339,0.006685708,0.01665696,0.005241975],"genre_scores_gemma":[0.08813595,0.0008953896,0.8818318,0.0004923709,0.00007170218,0.009785578,0.009465004,0.002144835,0.007177447],"genre_candidate":"methods","genre_consensus":"methods","teacher_disagreement_score":0.007815781,"threshold_uncertainty_score":0.04133427,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05343951200482576,"score_gpt":0.4070438318793414,"score_spread":0.3536043198745156,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}