{"id":"W3186887221","doi":"10.1139/cjpp-2020-0763","title":"S-ketamine alleviates carbon tetrachloride-induced hepatic injury and oxidative stress by targeting the Nrf2/HO-1 signaling pathway","year":2021,"lang":"en","type":"article","venue":"Canadian Journal of Physiology and Pharmacology","topic":"Drug-Induced Hepatotoxicity and Protection","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Oxidative stress; Superoxide dismutase; Aspartate transaminase; Liver injury; Glutathione; Alanine transaminase; Glutathione peroxidase; Malondialdehyde; Chemistry; Alkaline phosphatase; Liver cell; Pharmacology; Biochemistry; Biology; Internal medicine; Endocrinology; Medicine; Enzyme","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.001209469,0.0003270612,0.0005645807,0.0001837261,0.0007892249,0.0000320774,0.0002609272,0.0005321545,0.0007735652],"category_scores_gemma":[0.0002418407,0.0002718162,0.0001052161,0.0002636414,0.0005128977,0.0001745181,0.00006341172,0.002105976,0.000004090511],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001055892,"about_ca_system_score_gemma":0.0007658829,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006900887,"about_ca_topic_score_gemma":0.000776168,"domain_scores_codex":[0.9964015,0.001846173,0.0006255554,0.0003650408,0.0001016376,0.0006600695],"domain_scores_gemma":[0.997317,0.001109024,0.0004738572,0.0001104854,0.0003392188,0.0006504168],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000181549,0.00008005122,0.005062344,0.000103891,0.0004623788,0.0001891692,0.00156753,0.00008732482,0.9871683,0.0001100297,0.0009370682,0.00405043],"study_design_scores_gemma":[0.001215309,0.0003800569,0.001008459,0.00003028159,0.0002644122,0.0002162688,0.0006512529,0.0004954473,0.9796647,0.001047795,0.01474163,0.0002843439],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9892678,0.005097305,0.00001127773,0.002375946,0.002612612,0.0002852833,0.00009348184,0.00001430042,0.000241945],"genre_scores_gemma":[0.9950532,0.0008117236,0.00003392025,0.003104174,0.0008063634,0.00002528656,0.00002611668,0.00002690131,0.0001123322],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01380456,"threshold_uncertainty_score":0.9999734,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04415125090799341,"score_gpt":0.3353825619205496,"score_spread":0.2912313110125562,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}