{"id":"W3186899036","doi":"10.1093/hmg/ddab207","title":"Effective therapeutic strategies in a preclinical mouse model of Charcot–Marie–Tooth disease","year":2021,"lang":"en","type":"article","venue":"Human Molecular Genetics","topic":"Hereditary Neurological Disorders","field":"Neuroscience","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Instituto de Salud Carlos III; Ministerio de Economía y Competitividad; Arnie Charbonneau Cancer Institute, University of Calgary","keywords":"Biology; Pharmacology; Gene knockdown; Oxidative stress; Antioxidant; Florfenicol; Cancer research; Antibiotics; Biochemistry; Apoptosis","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001063902,0.0002017987,0.0002652295,0.0000671623,0.00005307358,0.0000435858,0.0003269886,0.000102125,0.00005771884],"category_scores_gemma":[0.0005462758,0.0002017802,0.0001379037,0.0002303364,0.000299523,0.0000604564,0.0001754986,0.0002961992,0.00001068493],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001683481,"about_ca_system_score_gemma":0.0001758908,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000003876288,"about_ca_topic_score_gemma":0.00002029358,"domain_scores_codex":[0.9977655,0.0005665587,0.0003606435,0.0006188165,0.0003540961,0.0003344007],"domain_scores_gemma":[0.9989268,0.0002549856,0.00007906997,0.0005402416,0.00005129476,0.0001476027],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005835604,0.0004751868,0.0008442877,0.00004177596,0.000007555746,0.0002081501,0.0001245857,0.05683055,0.9322072,0.008523493,0.00000479522,0.0006740232],"study_design_scores_gemma":[0.001707501,0.0006391015,0.03613862,0.00003107963,0.00006790368,0.000002971654,0.0000780407,0.09127432,0.755215,0.1141987,0.0001000196,0.0005467049],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.993721,0.0005849649,0.004185842,0.0001489628,0.00004243672,0.0004344589,0.00003682347,0.00004235477,0.0008031438],"genre_scores_gemma":[0.9981182,0.0001463949,0.0002159083,0.00134503,0.00001418768,0.00005088763,0.000007124687,0.00003526072,0.00006699887],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1769923,"threshold_uncertainty_score":0.8228357,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07187662447254675,"score_gpt":0.3349520023115582,"score_spread":0.2630753778390115,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}