{"id":"W3186899036","doi":"10.1093/hmg/ddab207","title":"Effective therapeutic strategies in a preclinical mouse model of Charcot–Marie–Tooth disease","year":2021,"lang":"en","type":"article","venue":"Human Molecular Genetics","topic":"Hereditary Neurological Disorders","field":"Neuroscience","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Instituto de Salud Carlos III; Ministerio de Economía y Competitividad; Arnie Charbonneau Cancer Institute, University of Calgary","keywords":"Biology; Pharmacology; Gene knockdown; Oxidative stress; Antioxidant; Florfenicol; Cancer research; Antibiotics; Biochemistry; Apoptosis","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006500927,0.00156766,0.0008539847,0.001341278,0.000660342,0.0007396033,0.0009629509,0.001644785,0.002265324],"category_scores_gemma":[0.0002429042,0.0003552436,0.0006752287,0.0003584216,0.0008356049,0.0007277938,0.0004579869,0.002709531,0.0007136491],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008663978,"about_ca_system_score_gemma":0.0008035034,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001659111,"about_ca_topic_score_gemma":0.004297676,"domain_scores_codex":[0.9995077,0.00008172318,0.00004935516,0.000124118,0.0001347902,0.0001023451],"domain_scores_gemma":[0.9997709,0.00002699858,0.00005421448,0.000027092,0.00002728903,0.00009345703],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005851222,0.0007116659,0.0001132503,0.000193175,0.00003342363,0.0003693333,0.00006226737,0.0002817671,0.9918589,0.0008456829,0.0006547304,0.004290544],"study_design_scores_gemma":[0.0006206228,0.007723821,0.00239665,0.000169881,0.0001812733,0.001359475,0.0001451526,0.002023982,0.959715,0.000780764,0.02483592,0.00004743463],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9563075,0.0113357,0.01383994,0.002275489,0.0009653095,0.0009893157,0.003412805,0.001265116,0.009608774],"genre_scores_gemma":[0.9427207,0.01305914,0.01954129,0.0008243299,0.0001174702,0.001672466,0.003203723,0.0001800273,0.01868093],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002265324,"threshold_uncertainty_score":0.007578313,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07187662447254675,"score_gpt":0.3349520023115582,"score_spread":0.2630753778390115,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}