{"id":"W3186920055","doi":"10.1371/journal.pgen.1009684","title":"An autoimmune disease risk variant: A trans master regulatory effect mediated by IRF1 under immune stimulation?","year":2021,"lang":"en","type":"article","venue":"PLoS Genetics","topic":"Cancer-related molecular mechanisms research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":35,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"H2020 Marie Skłodowska-Curie Actions; National Human Genome Research Institute; Canadian Institutes of Health Research; Horizon 2020 Framework Programme; National Institutes of Health; National Institute of General Medical Sciences; National Institute of Mental Health; American Heart Association","keywords":"Biology; Expression quantitative trait loci; Enhancer; IRF1; Genetics; Genome-wide association study; Immune system; Transcription factor; Regulation of gene expression; Gene; SNP; Locus (genetics); Autoimmune disease; Single-nucleotide polymorphism; Computational biology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006290226,0.0004457635,0.0005002496,0.0004179193,0.0002047717,0.0005177383,0.0003325323,0.0007182885,0.002680223],"category_scores_gemma":[0.0007073127,0.00019644,0.0007069248,0.0003189298,0.0005041862,0.0003099399,0.0003555554,0.0007387999,0.0005179289],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000348985,"about_ca_system_score_gemma":0.0002680764,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008284936,"about_ca_topic_score_gemma":0.001117284,"domain_scores_codex":[0.9995444,0.00006521251,0.0000313474,0.0001974888,0.00008559785,0.00007595622],"domain_scores_gemma":[0.9996711,0.0001119593,0.00009676325,0.00007118217,0.00002033393,0.00002865201],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006961245,0.00004181222,0.04916406,0.0002323022,0.0002295617,0.002331842,0.0002458761,0.0007923518,0.9188963,0.004615077,0.0004076743,0.02234699],"study_design_scores_gemma":[0.0002061058,0.0007699101,0.4963022,0.0002049471,0.001391601,0.02186248,0.0004458067,0.01207146,0.4269325,0.01375214,0.02590443,0.0001563388],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9725372,0.004076543,0.01758859,0.001075631,0.00008566434,0.00002095826,0.0013788,0.000264456,0.002972151],"genre_scores_gemma":[0.9937561,0.000557104,0.003867859,0.000308156,0.00002962104,0.00001349927,0.0004613118,0.00003248563,0.0009738855],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002680223,"threshold_uncertainty_score":0.008966208,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008689326374451689,"score_gpt":0.2497555326906167,"score_spread":0.241066206316165,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}