{"id":"W3186925921","doi":"10.1021/acscatal.1c02017","title":"An Overview of Cytochrome P450 Immobilization Strategies for Drug Metabolism Studies, Biosensing, and Biocatalytic Applications: Challenges and Opportunities","year":2021,"lang":"en","type":"article","venue":"ACS Catalysis","topic":"Enzyme Catalysis and Immobilization","field":"Biochemistry, Genetics and Molecular Biology","cited_by":44,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; PROTEO; Centre in Green Chemistry and Catalysis","funders":"Natural Sciences and Engineering Research Council of Canada; Universidad Complutense de Madrid; Comunidad de Madrid","keywords":"Cytochrome P450; Context (archaeology); Biosensor; Biochemical engineering; Drug metabolism; Chemistry; Biochemistry; Computational biology; Enzyme; Biology; Engineering","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006798646,0.001354922,0.001060493,0.002474134,0.000367096,0.001164768,0.0009014111,0.001279523,0.002514073],"category_scores_gemma":[0.0005003888,0.0006964098,0.0007618872,0.002671754,0.0003174008,0.001692235,0.0006122234,0.001602551,0.002963987],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006866399,"about_ca_system_score_gemma":0.0006546685,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006640314,"about_ca_topic_score_gemma":0.001078971,"domain_scores_codex":[0.9996112,0.00006211493,0.00004382514,0.00008639518,0.0001590185,0.00003745043],"domain_scores_gemma":[0.999764,0.00009521217,0.00003390765,0.00001509527,0.00007039693,0.00002131907],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00009462103,0.0002437886,0.0005035832,0.02479231,0.0001434245,0.0004517105,0.0001737902,0.001604388,0.09630333,0.01236755,0.03006451,0.8332571],"study_design_scores_gemma":[0.00001044506,0.0002803689,0.0008994701,0.001373176,0.0001033822,0.001519282,0.000062299,0.001000942,0.02118541,0.003054808,0.9704579,0.00005241461],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.001979498,0.9792734,0.01032197,0.0005778288,0.0005005677,0.00005650728,0.0001423769,0.0001170889,0.007030761],"genre_scores_gemma":[0.004425155,0.9801625,0.01051786,0.0004557311,0.0003963095,0.00008781963,0.0003152037,0.0000248706,0.003614502],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002514073,"threshold_uncertainty_score":0.008410394,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08816699186900347,"score_gpt":0.333336806752323,"score_spread":0.2451698148833196,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}