{"id":"W3186928577","doi":"10.1080/14737175.2021.1956904","title":"The <i>APOE</i> ε4 variant and hippocampal atrophy in Alzheimer’s disease and Lewy body dementia: a systematic review of magnetic resonance imaging studies and therapeutic relevance","year":2021,"lang":"en","type":"review","venue":"Expert Review of Neurotherapeutics","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":25,"is_retracted":false,"has_abstract":true,"ca_institutions":"Health Sciences Centre; University of Toronto; Sunnybrook Health Science Centre","funders":"Canadian Institutes of Health Research","keywords":"Lewy body; Apolipoprotein E; Dementia; Hippocampal formation; Atrophy; Neuroimaging; Neuroscience; Magnetic resonance imaging; Psychology; Alzheimer's disease; Dementia with Lewy bodies; Pittsburgh compound B; Medicine; Pathology; Disease; Oncology; Radiology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0008777077,0.0007325905,0.004612917,0.000114065,0.0001341545,0.00003695157,0.0002515487,0.00007186813,0.00001068417],"category_scores_gemma":[0.0005140417,0.0004308429,0.0004693165,0.0005077032,0.0006195776,0.00006882587,0.000235411,0.000380721,0.000001756187],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005075366,"about_ca_system_score_gemma":0.0004807819,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000006665808,"about_ca_topic_score_gemma":0.000001414681,"domain_scores_codex":[0.9946761,0.001508724,0.001865367,0.0007557614,0.0007206019,0.0004734054],"domain_scores_gemma":[0.9962617,0.001241765,0.0007998102,0.001095545,0.0002987994,0.0003024379],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"systematic_review","study_design_gemma":"systematic_review","study_design_scores_codex":[0.0000269406,0.0001219263,0.00003656379,0.7355338,0.003691551,0.0002856527,0.00003788088,1.914729e-9,6.52407e-7,0.0000860428,0.00007983735,0.2600991],"study_design_scores_gemma":[0.0005652658,0.0002258125,0.00004206734,0.8523253,0.02371497,0.0003271512,0.0000292458,0.000009276851,6.214289e-7,0.00004728473,0.1224409,0.0002721436],"study_design_candidate":"systematic_review","study_design_consensus":"systematic_review","genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.000002888645,0.9921373,0.000002270454,0.001044992,0.00006971831,0.006666423,0.00004776685,0.00001448949,0.00001419031],"genre_scores_gemma":[0.00004036755,0.9956705,0.0001555749,0.002890072,0.00004662506,0.001070546,0.00001963336,0.00009694797,0.00000975665],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.259827,"threshold_uncertainty_score":0.9998143,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05519063088171836,"score_gpt":0.389126496216665,"score_spread":0.3339358653349466,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}