{"id":"W3186976020","doi":"10.3390/ijms22147704","title":"Analysis of the Structural Mechanism of ATP Inhibition at the AAA1 Subunit of Cytoplasmic Dynein-1 Using a Chemical “Toolkit”","year":2021,"lang":"en","type":"article","venue":"International Journal of Molecular Sciences","topic":"Microtubule and mitosis dynamics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"Memorial University of Newfoundland","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Dynein; ATP hydrolysis; Protein subunit; Microtubule; Motor protein; Dynactin; Chemistry; Molecular motor; ATPase; Organelle; Biophysics; Stereochemistry; Binding site; Biochemistry; Protonation; Cytoplasm; Cell biology; Biology; Enzyme","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001200161,0.0002130463,0.0001510267,0.00008555054,0.00008531037,0.000139193,0.0003468232,0.0002100687,0.0009968042],"category_scores_gemma":[0.0001613323,0.0001226841,0.0002617732,0.00009832567,0.0001355333,0.000199994,0.00008605963,0.0003364026,0.0001727667],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002885633,"about_ca_system_score_gemma":0.0001505042,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007754301,"about_ca_topic_score_gemma":0.0005838077,"domain_scores_codex":[0.9999329,0.00001017366,0.000004144866,0.00001298662,0.00002399648,0.0000158419],"domain_scores_gemma":[0.9999317,0.00001888642,0.00002384177,0.000004895391,0.00001168262,0.000009002731],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002706827,0.00008573339,0.0008701343,0.0001709005,0.00002947181,0.0001574445,0.00002031594,0.003256075,0.9916987,0.0005112049,0.0001042058,0.002825047],"study_design_scores_gemma":[0.00004719928,0.0009188816,0.006134551,0.0000144705,0.00005802766,0.0002453291,0.00004631021,0.03833075,0.9515008,0.0001285327,0.00255488,0.00002024741],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9957364,0.001133925,0.001856927,0.00006838042,0.00001534105,0.00001897296,0.0001521649,0.00002838595,0.0009895143],"genre_scores_gemma":[0.9976441,0.0006025233,0.001111165,0.00001498838,0.000002608571,0.000008869805,0.0001852024,0.000004419212,0.0004261583],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009968042,"threshold_uncertainty_score":0.003334641,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01036846043154407,"score_gpt":0.2674076595373813,"score_spread":0.2570391991058373,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}