{"id":"W3186988040","doi":"10.1101/2021.07.23.453538","title":"Synthesis and characterization of peptide conjugated human serum albumin nanoparticles for targeted cardiac uptake and drug delivery","year":2021,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Nanoparticle-Based Drug Delivery","field":"Materials Science","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"Royal Victoria Hospital; Université de Montréal","funders":"Canadian Institutes of Health Research; Natural Sciences and Engineering Research Council of Canada; McGill University","keywords":"Pharmacology; Inotrope; Human serum albumin; Chemistry; Heart failure; In vivo; Drug delivery; Targeted drug delivery; Angiotensin II; Bioavailability; Pharmacokinetics; Albumin; Medicine; Drug; Internal medicine; Biochemistry; Receptor; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001756491,0.000260836,0.0001549442,0.0001531357,0.0000928755,0.0001622445,0.0001414283,0.0003211796,0.0003956491],"category_scores_gemma":[0.0001675217,0.00009857163,0.0001781919,0.00009048785,0.0001105401,0.000119828,0.0001060878,0.0001792651,0.0002301461],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000208129,"about_ca_system_score_gemma":0.0001127973,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003832995,"about_ca_topic_score_gemma":0.0004443533,"domain_scores_codex":[0.9998991,0.00001346239,0.000009901303,0.00002525379,0.00003882977,0.00001331657],"domain_scores_gemma":[0.9999253,0.00001124919,0.00002078837,0.000004546779,0.00002703009,0.00001110389],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002429502,0.00001263092,0.00006137493,0.00004393641,0.000003346319,0.00003939824,0.00001381053,0.0002056586,0.9978006,0.00004841143,0.00003821301,0.001708383],"study_design_scores_gemma":[0.00001127806,0.0002892296,0.001128536,0.000005919192,0.00001060838,0.0001274061,0.00001233338,0.00263511,0.9934592,0.00003283198,0.002279983,0.000007509467],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9663692,0.00263878,0.02790741,0.0001114535,0.00007158292,0.0002204447,0.0002994789,0.0001395103,0.002242293],"genre_scores_gemma":[0.9804562,0.0007354605,0.01489464,0.00008434071,0.00001295959,0.0001954992,0.0002757693,0.00002634057,0.003318821],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0003956491,"threshold_uncertainty_score":0.001510084,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01097526436121496,"score_gpt":0.2042239254483459,"score_spread":0.1932486610871309,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}