{"id":"W3187296608","doi":"10.1016/j.jchf.2021.05.005","title":"Sex-Related Risk of Cardiac Involvement in Hereditary Transthyretin Amyloidosis","year":2021,"lang":"en","type":"article","venue":"JACC Heart Failure","topic":"Amyloidosis: Diagnosis, Treatment, Outcomes","field":"Biochemistry, Genetics and Molecular Biology","cited_by":76,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Centre Hospitalier Universitaire de Bordeaux; Aarhus Universitetshospital; Università Cattolica del Sacro Cuore; University of Maryland; School of Medicine, Stanford University; Istanbul Üniversitesi; Centre hospitalier universitaire Sainte-Justine; Pfizer; Johns Hopkins Hospital; University of Colorado Denver; Celgene; Array BioPharma","keywords":"Transthyretin; Amyloidosis; Medicine; Internal medicine; Cardiomyopathy; Cardiac amyloidosis; Ejection fraction; Asymptomatic; Cardiology; Gastroenterology; Genotype; Amyloid disease; Restrictive cardiomyopathy; Disease; Heart failure; Amyloid fibril; Biology; Genetics","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0003115296,0.0002832617,0.000506637,0.00008049163,0.00006112647,0.00001590086,0.0001565973,0.0003481574,0.0001901574],"category_scores_gemma":[0.0001109793,0.0002819343,0.000378894,0.0003030841,0.00008331284,0.000008288318,0.0001097515,0.000226501,0.00003062193],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005301747,"about_ca_system_score_gemma":0.000173015,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003513487,"about_ca_topic_score_gemma":0.0006745741,"domain_scores_codex":[0.9979258,0.0003571728,0.0005046114,0.0005812457,0.0002463942,0.0003848218],"domain_scores_gemma":[0.9989774,0.00006382151,0.0001148,0.0006188321,0.00009879776,0.0001263489],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000358714,0.000435094,0.7601,0.00005862444,0.0005116042,0.0000251284,0.0003476123,0.0001284694,0.2132432,0.00002212588,0.02352674,0.001565475],"study_design_scores_gemma":[0.001467762,0.0002673915,0.1706163,0.00007132758,0.000158596,0.00001140125,0.00141997,0.00001371597,0.736767,0.0000568063,0.08876055,0.000389207],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9912811,0.004703742,0.00001217543,0.002985383,0.0002111127,0.0003438394,0.0002039592,0.00002272032,0.0002360027],"genre_scores_gemma":[0.9948726,0.00149518,0.002175942,0.000370157,0.0001132418,0.0001130949,0.0003936609,0.00004456569,0.0004215631],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.5894837,"threshold_uncertainty_score":0.9999633,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00631975124312009,"score_gpt":0.2316662205275827,"score_spread":0.2253464692844626,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}